Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise
It remains unclear whether sickle cell trait (SCT) should be considered a risk factor during intense physical activity. By triggering the polymerization-sickling-vaso-occlusion cascade, lactate accumulation-associated acidosis in response to high-intensity exercise is believed to be one of the cause...
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/501 |
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| author | Laurent A. Messonnier Samuel Oyono-Enguéllé Lucile Vincent Hervé Dubouchaud Benjamin Chatel Hervé Sanchez Alexandra Malgoyre Cyril Martin Frédéric Galactéros Pablo Bartolucci Patrice Thiriet Léonard Féasson |
| author_facet | Laurent A. Messonnier Samuel Oyono-Enguéllé Lucile Vincent Hervé Dubouchaud Benjamin Chatel Hervé Sanchez Alexandra Malgoyre Cyril Martin Frédéric Galactéros Pablo Bartolucci Patrice Thiriet Léonard Féasson |
| author_sort | Laurent A. Messonnier |
| collection | DOAJ |
| description | It remains unclear whether sickle cell trait (SCT) should be considered a risk factor during intense physical activity. By triggering the polymerization-sickling-vaso-occlusion cascade, lactate accumulation-associated acidosis in response to high-intensity exercise is believed to be one of the causes of complications. However, our understanding of lactate metabolism in response to high-intensity exercise in SCT carriers is incomplete. Thirty male SCT carriers (<i>n</i> = 15) and healthy subjects (<i>n</i> = 15) with and without α-thalassemia performed a 2-min high-intensity exercise. Blood and muscle lactate concentrations were measured at exercise completion. Time courses of blood lactate and glucose concentrations were followed during the subsequent recovery. Additional biochemical analyses were performed on biopsies of the <i>vastus lateralis</i> muscle. SCT was associated with lower blood and muscle lactate concentrations in response to the short high-intensity exercise. Compared to controls, the muscle content among SCT carriers of lactate transporter MCT4 and β<sub>2</sub>-adrenergic receptor were higher and lower, respectively. During recovery, the lactate removal ability was higher in SCT carriers. In the present study, no effect of α-thalassemia was observed. The lower blood and muscle lactate accumulations in SCT carriers may, to some extent, act as protective mechanisms: (i) against exercise-related acidosis and subsequent sickling, that may explain the relatively rare complications observed in exercising SCT carriers; and (ii) against the deleterious effects of intracellular lactate and associated acidosis on muscle function, that might explain the elevated presence of SCT carriers among the best sprinters. |
| first_indexed | 2024-03-09T23:22:42Z |
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| id | doaj.art-a5fd310a5fa24862a03baa01249606dc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:22:42Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a5fd310a5fa24862a03baa01249606dc2023-11-23T17:24:48ZengMDPI AGNutrients2072-66432022-01-0114350110.3390/nu14030501Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity ExerciseLaurent A. Messonnier0Samuel Oyono-Enguéllé1Lucile Vincent2Hervé Dubouchaud3Benjamin Chatel4Hervé Sanchez5Alexandra Malgoyre6Cyril Martin7Frédéric Galactéros8Pablo Bartolucci9Patrice Thiriet10Léonard Féasson11Université Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-73000 Chambéry, FranceUniversité de Yaoundé 1, Laboratoire de Physiologie, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, CameroonUniversité Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-73000 Chambéry, FranceUniversité Grenoble Alpes, Inserm, LBFA, F-38000 Grenoble, FranceUniversité Savoie Mont Blanc, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-73000 Chambéry, FranceInstitut de Recherche Biomédicale des Armées, Unité Physiologie de l’Exercice et des Activités en Conditions Extrêmes, F-91223 Brétigny-sur-Orge, FranceInstitut de Recherche Biomédicale des Armées, Unité Physiologie de l’Exercice et des Activités en Conditions Extrêmes, F-91223 Brétigny-sur-Orge, FranceUniversité de Lyon, Université Claude Bernard Lyon 1, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-69100 Villeurbanne, FranceSickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital-UPEC, AP-HP, F-94000 Créteil, FranceSickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital-UPEC, AP-HP, F-94000 Créteil, FranceUniversité de Lyon, Université Claude Bernard Lyon 1, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-69100 Villeurbanne, FranceUniversité de Lyon, Université Jean Monnet Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-42000 Saint-Etienne, FranceIt remains unclear whether sickle cell trait (SCT) should be considered a risk factor during intense physical activity. By triggering the polymerization-sickling-vaso-occlusion cascade, lactate accumulation-associated acidosis in response to high-intensity exercise is believed to be one of the causes of complications. However, our understanding of lactate metabolism in response to high-intensity exercise in SCT carriers is incomplete. Thirty male SCT carriers (<i>n</i> = 15) and healthy subjects (<i>n</i> = 15) with and without α-thalassemia performed a 2-min high-intensity exercise. Blood and muscle lactate concentrations were measured at exercise completion. Time courses of blood lactate and glucose concentrations were followed during the subsequent recovery. Additional biochemical analyses were performed on biopsies of the <i>vastus lateralis</i> muscle. SCT was associated with lower blood and muscle lactate concentrations in response to the short high-intensity exercise. Compared to controls, the muscle content among SCT carriers of lactate transporter MCT4 and β<sub>2</sub>-adrenergic receptor were higher and lower, respectively. During recovery, the lactate removal ability was higher in SCT carriers. In the present study, no effect of α-thalassemia was observed. The lower blood and muscle lactate accumulations in SCT carriers may, to some extent, act as protective mechanisms: (i) against exercise-related acidosis and subsequent sickling, that may explain the relatively rare complications observed in exercising SCT carriers; and (ii) against the deleterious effects of intracellular lactate and associated acidosis on muscle function, that might explain the elevated presence of SCT carriers among the best sprinters.https://www.mdpi.com/2072-6643/14/3/501lactate transportpH regulationgluconeogenesisrecovery |
| spellingShingle | Laurent A. Messonnier Samuel Oyono-Enguéllé Lucile Vincent Hervé Dubouchaud Benjamin Chatel Hervé Sanchez Alexandra Malgoyre Cyril Martin Frédéric Galactéros Pablo Bartolucci Patrice Thiriet Léonard Féasson Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise Nutrients lactate transport pH regulation gluconeogenesis recovery |
| title | Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise |
| title_full | Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise |
| title_fullStr | Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise |
| title_full_unstemmed | Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise |
| title_short | Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise |
| title_sort | lower muscle and blood lactate accumulation in sickle cell trait carriers in response to short high intensity exercise |
| topic | lactate transport pH regulation gluconeogenesis recovery |
| url | https://www.mdpi.com/2072-6643/14/3/501 |
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