New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease
Halting the reduction in glomerular filtration rate (GFR) is the primary aim of any treatment of patients presenting with progressive chronic renal failure, a very common corollary to diabetes. To improve GFR, the high blood pressure (BP) and proteinuria often seen in these patients must both be con...
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| Format: | Article |
| Language: | English |
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SAGE Publications
2000-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | http://jra.sagepub.com/content/1/2_suppl/S29.full.pdf |
| _version_ | 1797284233334489088 |
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| author | Luis M Ruilope |
| author_facet | Luis M Ruilope |
| author_sort | Luis M Ruilope |
| collection | DOAJ |
| description | Halting the reduction in glomerular filtration rate (GFR) is the primary aim of any treatment of patients presenting with progressive chronic renal failure, a very common corollary to diabetes. To improve GFR, the high blood pressure (BP) and proteinuria often seen in these patients must both be controlled. These symptoms lead not only to progressive loss of renal function, but also to an increase in cardiovascular risk. Use of angiotensin-converting enzyme (ACE) inhibitors in these patients has been reported to control BP and reduce protein excretion and cardiovascular risk. Complete blockade of angiotensin II (Ang II) action with the highly selective Ang II receptor blocker (ARB) valsartan, both as monotherapy and in combination with ACE inhibitors, is well-tolerated and efficacious in patients with renal failure. Unlike ACE inhibition, ARB treatment leads to no initial reduction in GFR, thus valsartan may be a better agent for the control of BP, with greater renal protection. |
| first_indexed | 2024-03-07T17:45:06Z |
| format | Article |
| id | doaj.art-a5fdf50a4cfb4d52aaf7961bee0e1e2d |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:45:06Z |
| publishDate | 2000-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-a5fdf50a4cfb4d52aaf7961bee0e1e2d2024-03-02T15:18:15ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762000-06-0112_supplS29S3110.3317/jraas.2000.05110.3317_jraas.2000.051New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal diseaseLuis M Ruilope0Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain, Luis_M_Ruilope @teleline.esHalting the reduction in glomerular filtration rate (GFR) is the primary aim of any treatment of patients presenting with progressive chronic renal failure, a very common corollary to diabetes. To improve GFR, the high blood pressure (BP) and proteinuria often seen in these patients must both be controlled. These symptoms lead not only to progressive loss of renal function, but also to an increase in cardiovascular risk. Use of angiotensin-converting enzyme (ACE) inhibitors in these patients has been reported to control BP and reduce protein excretion and cardiovascular risk. Complete blockade of angiotensin II (Ang II) action with the highly selective Ang II receptor blocker (ARB) valsartan, both as monotherapy and in combination with ACE inhibitors, is well-tolerated and efficacious in patients with renal failure. Unlike ACE inhibition, ARB treatment leads to no initial reduction in GFR, thus valsartan may be a better agent for the control of BP, with greater renal protection.http://jra.sagepub.com/content/1/2_suppl/S29.full.pdf |
| spellingShingle | Luis M Ruilope New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease Journal of the Renin-Angiotensin-Aldosterone System |
| title | New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease |
| title_full | New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease |
| title_fullStr | New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease |
| title_full_unstemmed | New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease |
| title_short | New clinical investigations with selective angiotensin II receptor blocker therapy in diabetes and renal disease |
| title_sort | new clinical investigations with selective angiotensin ii receptor blocker therapy in diabetes and renal disease |
| url | http://jra.sagepub.com/content/1/2_suppl/S29.full.pdf |
| work_keys_str_mv | AT luismruilope newclinicalinvestigationswithselectiveangiotensiniireceptorblockertherapyindiabetesandrenaldisease |