Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection
Abstract Background Oral squamous cell carcinoma (OSCC) is the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting survival prognosis in patients with locally advanced oral squamous cell ca...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-08106-x |
| _version_ | 1818966198976512000 |
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| author | Zhiliang Nie Pengcheng Zhao Yishan Shang Bo Sun |
| author_facet | Zhiliang Nie Pengcheng Zhao Yishan Shang Bo Sun |
| author_sort | Zhiliang Nie |
| collection | DOAJ |
| description | Abstract Background Oral squamous cell carcinoma (OSCC) is the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting survival prognosis in patients with locally advanced oral squamous cell carcinoma (OSCC) after curative resection. Methods A total of 269 consecutive patients with primary OSCC who received curative resection between September 2007 and March 2020 were retrospectively enrolled in our study. Patients were randomly assigned to the training cohort (n = 201) or the validation cohort (n = 68). Multivariate Cox regression analyses were conducted to determine independent prognostic factors for overall survival (OS) and cancer specific survival (CSS) in the training set, which were used to develop nomogram models estimating 3-, and 5-year OS and CSS. We also evaluated the nomograms using concordance indices (c-index), calibration curves, and decision curve analyses (DCA), and compared those with the AJCC 8th staging system. The results were externally validated in the validation cohort. Results Age, Kaplan-Feinstein (KFI) index, pT, the number of positive nodes and systemic inflammatory index (SII) were significant prognostic predictors for OS and CSS. The OS nomogram had c-index values of 0.712 in the training set and 0.697 in the validation set, while the CSS nomogram exhibited c-index values of 0.709 in the training set and 0.675 in the validation set. These data were superior to those of AJCC 8th staging system, suggesting high discriminative ability of the nomograms. Calibration curves exhibited good agreement between observed and predicted survival. DCA curves indicated the nomograms were with potential clinical usefulness. These results were validated in the validation set. Conclusions The novel nomograms incorporating clinically available characteristics for OS and CSS prediction were developed in the locally advanced OSCC patients after curative surgery. Validation revealed good discrimination and calibration, indicating the clinical utility of the nomograms in the individualized prognosis prediction of locally advanced OSCC after curative surgery. |
| first_indexed | 2024-12-20T13:29:06Z |
| format | Article |
| id | doaj.art-a5fec626aa2f4601a834f50c36161bbd |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T13:29:06Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a5fec626aa2f4601a834f50c36161bbd2022-12-21T19:39:10ZengBMCBMC Cancer1471-24072021-04-0121111710.1186/s12885-021-08106-xNomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resectionZhiliang Nie0Pengcheng Zhao1Yishan Shang2Bo Sun3First Affiliated Hospital of Gannan Medical UniversitySchool of Stomatology, Dalian Medical UniversityDalian Municipal Women and Children’s Medical CenterThe Second Hospital of Dalian Medical UniversityAbstract Background Oral squamous cell carcinoma (OSCC) is the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting survival prognosis in patients with locally advanced oral squamous cell carcinoma (OSCC) after curative resection. Methods A total of 269 consecutive patients with primary OSCC who received curative resection between September 2007 and March 2020 were retrospectively enrolled in our study. Patients were randomly assigned to the training cohort (n = 201) or the validation cohort (n = 68). Multivariate Cox regression analyses were conducted to determine independent prognostic factors for overall survival (OS) and cancer specific survival (CSS) in the training set, which were used to develop nomogram models estimating 3-, and 5-year OS and CSS. We also evaluated the nomograms using concordance indices (c-index), calibration curves, and decision curve analyses (DCA), and compared those with the AJCC 8th staging system. The results were externally validated in the validation cohort. Results Age, Kaplan-Feinstein (KFI) index, pT, the number of positive nodes and systemic inflammatory index (SII) were significant prognostic predictors for OS and CSS. The OS nomogram had c-index values of 0.712 in the training set and 0.697 in the validation set, while the CSS nomogram exhibited c-index values of 0.709 in the training set and 0.675 in the validation set. These data were superior to those of AJCC 8th staging system, suggesting high discriminative ability of the nomograms. Calibration curves exhibited good agreement between observed and predicted survival. DCA curves indicated the nomograms were with potential clinical usefulness. These results were validated in the validation set. Conclusions The novel nomograms incorporating clinically available characteristics for OS and CSS prediction were developed in the locally advanced OSCC patients after curative surgery. Validation revealed good discrimination and calibration, indicating the clinical utility of the nomograms in the individualized prognosis prediction of locally advanced OSCC after curative surgery.https://doi.org/10.1186/s12885-021-08106-xOral squamous cell carcinomaNomogramCancer managementPrognosis |
| spellingShingle | Zhiliang Nie Pengcheng Zhao Yishan Shang Bo Sun Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection BMC Cancer Oral squamous cell carcinoma Nomogram Cancer management Prognosis |
| title | Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| title_full | Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| title_fullStr | Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| title_full_unstemmed | Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| title_short | Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| title_sort | nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection |
| topic | Oral squamous cell carcinoma Nomogram Cancer management Prognosis |
| url | https://doi.org/10.1186/s12885-021-08106-x |
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