Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies

Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible...

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Bibliographic Details
Main Authors: Kentaro Nakayama, Naomi Nakayama, Masako Ishikawa, Kohji Miyazaki
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/4/3/799
Description
Summary:Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC.
ISSN:2072-6694