Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i>
Natural products are small molecules naturally produced by multiple sources such as plants, animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by modulating biological targets and pathways involved in oxidative stress and antioxidant response. Natural products’...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/705 |
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| author | An Zhu Fuli Zheng Wenjing Zhang Ludi Li Yingzi Li Hong Hu Yajiao Wu Wenqiang Bao Guojun Li Qi Wang Huangyuan Li |
| author_facet | An Zhu Fuli Zheng Wenjing Zhang Ludi Li Yingzi Li Hong Hu Yajiao Wu Wenqiang Bao Guojun Li Qi Wang Huangyuan Li |
| author_sort | An Zhu |
| collection | DOAJ |
| description | Natural products are small molecules naturally produced by multiple sources such as plants, animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by modulating biological targets and pathways involved in oxidative stress and antioxidant response. Natural products’ oxidative or antioxidative properties are usually investigated in preclinical experimental models, including virtual computing simulations, cell and tissue cultures, rodent and nonhuman primate animal models, and human studies. Due to the renewal of the concept of experimental animals, especially the popularization of alternative 3R methods for reduction, replacement and refinement, many assessment experiments have been carried out in new alternative models. The model organism <i>Caenorhabditis elegans</i> has been used for medical research since Sydney Brenner revealed its genetics in 1974 and has been introduced into pharmacology and toxicology in the past two decades. The data from <i>C. elegans</i> have been satisfactorily correlated with traditional experimental models. In this review, we summarize the advantages of <i>C. elegans</i> in assessing oxidative and antioxidative properties of natural products and introduce methods to construct an oxidative damage model in <i>C. elegans</i>. The biomarkers and signaling pathways involved in the oxidative stress of <i>C. elegans</i> are summarized, as well as the oxidation and antioxidation in target organs of the muscle, nervous, digestive and reproductive systems. This review provides an overview of the oxidative and antioxidative properties of natural products based on the model organism <i>C. elegans</i>. |
| first_indexed | 2024-03-09T11:14:13Z |
| format | Article |
| id | doaj.art-a60129cbf2584456ba79ed2f764e6aad |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:13Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a60129cbf2584456ba79ed2f764e6aad2023-12-01T00:35:28ZengMDPI AGAntioxidants2076-39212022-04-0111470510.3390/antiox11040705Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i>An Zhu0Fuli Zheng1Wenjing Zhang2Ludi Li3Yingzi Li4Hong Hu5Yajiao Wu6Wenqiang Bao7Guojun Li8Qi Wang9Huangyuan Li10Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350108, ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, ChinaDepartment of Toxicology, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Toxicology, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350108, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, ChinaDepartment of Toxicology, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350108, ChinaNatural products are small molecules naturally produced by multiple sources such as plants, animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by modulating biological targets and pathways involved in oxidative stress and antioxidant response. Natural products’ oxidative or antioxidative properties are usually investigated in preclinical experimental models, including virtual computing simulations, cell and tissue cultures, rodent and nonhuman primate animal models, and human studies. Due to the renewal of the concept of experimental animals, especially the popularization of alternative 3R methods for reduction, replacement and refinement, many assessment experiments have been carried out in new alternative models. The model organism <i>Caenorhabditis elegans</i> has been used for medical research since Sydney Brenner revealed its genetics in 1974 and has been introduced into pharmacology and toxicology in the past two decades. The data from <i>C. elegans</i> have been satisfactorily correlated with traditional experimental models. In this review, we summarize the advantages of <i>C. elegans</i> in assessing oxidative and antioxidative properties of natural products and introduce methods to construct an oxidative damage model in <i>C. elegans</i>. The biomarkers and signaling pathways involved in the oxidative stress of <i>C. elegans</i> are summarized, as well as the oxidation and antioxidation in target organs of the muscle, nervous, digestive and reproductive systems. This review provides an overview of the oxidative and antioxidative properties of natural products based on the model organism <i>C. elegans</i>.https://www.mdpi.com/2076-3921/11/4/705natural products<i>Caenorhabditis elegans</i>antioxidationoxidative stressreactive oxygen species |
| spellingShingle | An Zhu Fuli Zheng Wenjing Zhang Ludi Li Yingzi Li Hong Hu Yajiao Wu Wenqiang Bao Guojun Li Qi Wang Huangyuan Li Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> Antioxidants natural products <i>Caenorhabditis elegans</i> antioxidation oxidative stress reactive oxygen species |
| title | Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> |
| title_full | Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> |
| title_fullStr | Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> |
| title_short | Oxidation and Antioxidation of Natural Products in the Model Organism <i>Caenorhabditis elegans</i> |
| title_sort | oxidation and antioxidation of natural products in the model organism i caenorhabditis elegans i |
| topic | natural products <i>Caenorhabditis elegans</i> antioxidation oxidative stress reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/11/4/705 |
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