Mapping Epitopes Recognised by Autoantibodies Shows Potential for the Diagnosis of High-Grade Serous Ovarian Cancer and Monitoring Response to Therapy for This Malignancy

Mapping Epitopes Recognised by Autoantibodies Shows Potential for the Diagnosis of High-Grade Serous Ovarian Cancer and Monitoring Response to Therapy for This Malignancy

Autoantibodies recognising phosphorylated heat shock factor 1 (HSF1-PO4) protein are suggested as potential new diagnostic biomarkers for early-stage high-grade serous ovarian cancer (HGSOC). We predicted in silico B-cell epitopes in human and murine HSF1. Three epitope regions were synthesised as p...

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Bibliographic Details
Main Authors: Rhiane Moody, Kirsty Wilson, Nirmala Chandralega Kampan, Orla M. McNally, Thomas W. Jobling, Anthony Jaworowski, Andrew N. Stephens, Magdalena Plebanski
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
HSF1
epitope mapping
ovarian cancer peptides
IgA
biomarkers
Online Access:https://www.mdpi.com/2072-6694/13/16/4201

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