Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females
Abstract Background African Americans (AA) develop hypertension (HTN) at an earlier age, have a greater frequency and severity of HTN, and greater prevalence of uncontrolled HTN as compared to the white population. Mineralocorticoid antagonists have been shown to be very effective in treating uncont...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13293-019-0238-6 |
| _version_ | 1811225765843304448 |
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| author | John S. Clemmer Jessica L. Faulkner Alex J. Mullen Kenneth R. Butler Robert L. Hester |
| author_facet | John S. Clemmer Jessica L. Faulkner Alex J. Mullen Kenneth R. Butler Robert L. Hester |
| author_sort | John S. Clemmer |
| collection | DOAJ |
| description | Abstract Background African Americans (AA) develop hypertension (HTN) at an earlier age, have a greater frequency and severity of HTN, and greater prevalence of uncontrolled HTN as compared to the white population. Mineralocorticoid antagonists have been shown to be very effective in treating uncontrolled HTN in both AA and white patients, but sex-specific responses are unclear. Methods We evaluated the sex-specific impact of mineralocorticoid antagonism in an AA population. An AA cohort (n = 1483) from the Genetic Epidemiology Network of Arteriopathy study was stratified based on sex and whether they were taking spironolactone, a mineralocorticoid antagonist, in their antihypertensive regimen. Results As compared to AA women not prescribed a mineralocorticoid antagonist, AA women taking spironolactone (n = 9) had lower systolic and diastolic blood pressure despite having a similar number of antihypertensive medications. The proportion of AA women with uncontrolled HTN was significantly less for patients taking spironolactone than for patients not prescribed spironolactone. Interestingly, none of these associations were found in the AA males or in white females. Conclusions Our data suggests that spironolactone is particularly effective in reducing blood pressure and controlling HTN in AA women. Further research into the impact of this therapy in this underserved and understudied minority is warranted. |
| first_indexed | 2024-04-12T09:12:53Z |
| format | Article |
| id | doaj.art-a60463a2ec8e4f59936bf012d1584d1a |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-12T09:12:53Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-a60463a2ec8e4f59936bf012d1584d1a2022-12-22T03:38:55ZengBMCBiology of Sex Differences2042-64102019-05-011011710.1186/s13293-019-0238-6Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and femalesJohn S. Clemmer0Jessica L. Faulkner1Alex J. Mullen2Kenneth R. Butler3Robert L. Hester4Department of Physiology and Biophysics, Center for Computational Medicine, University of Mississippi Medical CenterVascular Biology Center, Medical College of Georgia, Augusta UniversityDepartment of Physiology and Biophysics, Center for Computational Medicine, University of Mississippi Medical CenterDepartment of Medicine, University of Mississippi Medical CenterDepartment of Physiology and Biophysics, Center for Computational Medicine, University of Mississippi Medical CenterAbstract Background African Americans (AA) develop hypertension (HTN) at an earlier age, have a greater frequency and severity of HTN, and greater prevalence of uncontrolled HTN as compared to the white population. Mineralocorticoid antagonists have been shown to be very effective in treating uncontrolled HTN in both AA and white patients, but sex-specific responses are unclear. Methods We evaluated the sex-specific impact of mineralocorticoid antagonism in an AA population. An AA cohort (n = 1483) from the Genetic Epidemiology Network of Arteriopathy study was stratified based on sex and whether they were taking spironolactone, a mineralocorticoid antagonist, in their antihypertensive regimen. Results As compared to AA women not prescribed a mineralocorticoid antagonist, AA women taking spironolactone (n = 9) had lower systolic and diastolic blood pressure despite having a similar number of antihypertensive medications. The proportion of AA women with uncontrolled HTN was significantly less for patients taking spironolactone than for patients not prescribed spironolactone. Interestingly, none of these associations were found in the AA males or in white females. Conclusions Our data suggests that spironolactone is particularly effective in reducing blood pressure and controlling HTN in AA women. Further research into the impact of this therapy in this underserved and understudied minority is warranted.http://link.springer.com/article/10.1186/s13293-019-0238-6Sex-specificHypertensionMineralocorticoid antagonistAfrican American |
| spellingShingle | John S. Clemmer Jessica L. Faulkner Alex J. Mullen Kenneth R. Butler Robert L. Hester Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females Biology of Sex Differences Sex-specific Hypertension Mineralocorticoid antagonist African American |
| title | Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females |
| title_full | Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females |
| title_fullStr | Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females |
| title_full_unstemmed | Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females |
| title_short | Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females |
| title_sort | sex specific responses to mineralocorticoid receptor antagonism in hypertensive african american males and females |
| topic | Sex-specific Hypertension Mineralocorticoid antagonist African American |
| url | http://link.springer.com/article/10.1186/s13293-019-0238-6 |
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