Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents

Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents

In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and studied. Chloramphenicol amine (CAM), derived from th...

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Bibliographic Details
Main Authors: Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antibiotics
Subjects:
chloramphenicol
berberine
C-13 derivatives of berberine
bacterial ribosome
bacterial membrane potential
antibiotic activity
Online Access:https://www.mdpi.com/2079-6382/12/1/15

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