Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases
Background : Axillary ultrasonography is a non-invasive and sensitive method used in the evaluation of breast cancer. We sought to evaluate the value of axillary ultrasonography in the nodal staging of breast cancer patients with axillary lymph node metastases.Methods : From a retrospective database...
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| Format: | Article |
| Language: | English |
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The Korean Surgical Ultrasound Society
2021-11-01
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| Series: | Journal of Surgical Ultrasound |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.46268/jsu.2021.8.2.41 |
| _version_ | 1818736690637832192 |
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| author | Jung Ho Park Hyun Ryung Kim Sanghwa Kim Young Ah Lim Kyoonsoon Jung Lee Su Kim |
| author_facet | Jung Ho Park Hyun Ryung Kim Sanghwa Kim Young Ah Lim Kyoonsoon Jung Lee Su Kim |
| author_sort | Jung Ho Park |
| collection | DOAJ |
| description | Background : Axillary ultrasonography is a non-invasive and sensitive method used in the evaluation of breast cancer. We sought to evaluate the value of axillary ultrasonography in the nodal staging of breast cancer patients with axillary lymph node metastases.Methods : From a retrospective database, we reviewed the electronic medical records of breast cancer patients with axillary lymph node metastases who underwent curative surgery between 2003 and 2020. We collected the relevant clinicopathological data and ultrasonographic images. We performed a binary logistic regression analysis to evaluate the factors associated with a high nodal stage.Results : A total of 563 patients were included. Total mastectomy, larger tumor size, abnormal axillary ultrasonography, high histologic grade, lymphatic invasion, hormonal receptor negativity, and HER2 receptor positivity were associated with a pN2 or higher nodal stage. A receiver-operator curve analysis revealed that two or more abnormal lymph nodes seen on axillary ultrasonography identified a high nodal stage with a sensitivity of 62.2% and a specificity of 85.3%. Multivariate analysis revealed that patient age less than 50, lymphatic invasion, two or more abnormal lymph nodes, and hilar effacement were independent predictive factors for the high nodal stage.Conclusion : In patients with two or more abnormal lymph nodes on axillary ultrasonography, upfront axillary lymph node dissection or neoadjuvant chemotherapy is preferred. Our findings highlight the importance of axillary ultrasonography in the nodal staging of breast cancer. |
| first_indexed | 2024-12-18T00:41:10Z |
| format | Article |
| id | doaj.art-a6063cb597424d6f8a5e41c34af04177 |
| institution | Directory Open Access Journal |
| issn | 2288-9140 |
| language | English |
| last_indexed | 2024-12-18T00:41:10Z |
| publishDate | 2021-11-01 |
| publisher | The Korean Surgical Ultrasound Society |
| record_format | Article |
| series | Journal of Surgical Ultrasound |
| spelling | doaj.art-a6063cb597424d6f8a5e41c34af041772022-12-21T21:26:53ZengThe Korean Surgical Ultrasound SocietyJournal of Surgical Ultrasound2288-91402021-11-0182414710.46268/jsu.2021.8.2.41jsu.2021.8.2.41Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node MetastasesJung Ho Park0Hyun Ryung Kim1Sanghwa Kim2Young Ah Lim3Kyoonsoon Jung4Lee Su Kim5Division of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang, KoreaDivision of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang, KoreaDivision of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang, KoreaDepartment of Surgery, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, KoreaDepartment of Radiology, Hallym University Sacred Heart Hospital, Anyang, KoreaDivision of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang, KoreaBackground : Axillary ultrasonography is a non-invasive and sensitive method used in the evaluation of breast cancer. We sought to evaluate the value of axillary ultrasonography in the nodal staging of breast cancer patients with axillary lymph node metastases.Methods : From a retrospective database, we reviewed the electronic medical records of breast cancer patients with axillary lymph node metastases who underwent curative surgery between 2003 and 2020. We collected the relevant clinicopathological data and ultrasonographic images. We performed a binary logistic regression analysis to evaluate the factors associated with a high nodal stage.Results : A total of 563 patients were included. Total mastectomy, larger tumor size, abnormal axillary ultrasonography, high histologic grade, lymphatic invasion, hormonal receptor negativity, and HER2 receptor positivity were associated with a pN2 or higher nodal stage. A receiver-operator curve analysis revealed that two or more abnormal lymph nodes seen on axillary ultrasonography identified a high nodal stage with a sensitivity of 62.2% and a specificity of 85.3%. Multivariate analysis revealed that patient age less than 50, lymphatic invasion, two or more abnormal lymph nodes, and hilar effacement were independent predictive factors for the high nodal stage.Conclusion : In patients with two or more abnormal lymph nodes on axillary ultrasonography, upfront axillary lymph node dissection or neoadjuvant chemotherapy is preferred. Our findings highlight the importance of axillary ultrasonography in the nodal staging of breast cancer.http://journaleditor.inforang.com/journal/view.html?doi=10.46268/jsu.2021.8.2.41breastaxillalymph nodeultrasonography |
| spellingShingle | Jung Ho Park Hyun Ryung Kim Sanghwa Kim Young Ah Lim Kyoonsoon Jung Lee Su Kim Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases Journal of Surgical Ultrasound breast axilla lymph node ultrasonography |
| title | Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases |
| title_full | Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases |
| title_fullStr | Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases |
| title_full_unstemmed | Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases |
| title_short | Clinical Value of Axillary Ultrasonography in Breast Cancer with Lymph Node Metastases |
| title_sort | clinical value of axillary ultrasonography in breast cancer with lymph node metastases |
| topic | breast axilla lymph node ultrasonography |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.46268/jsu.2021.8.2.41 |
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