Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes

Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes

Manganese (Mn) is an essential trace element that maintains many normal physiological functions. However, multi-system disorders would occur once overexposure to Mn, especially neurotoxicity. Despite evidence demonstrating the critical role of ROS-activated JNK/FOXO3a signaling pathway in neuronal s...

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Bibliographic Details
Main Authors: Wan-He Li, Zheng-Ting-Yan Xiang, An-Xin Lu, Su-Su Wang, Chong-Huai Yan
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Manganese
Neurotoxicity
Reactive oxygen species
Apoptosis
JNK/FOXO3a
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323008308

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