BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation

BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation

Abstract Bone morphogenetic protein 2 (BMP2) is highly overexpressed in human non-small cell lung cancer (NSCLC) and correlates with tumor stage and metastatic burden. Although several lines of evidence suggest that BMP2 promotes cell migration and invasiveness in vitro, the in vivo role of BMP2 in...

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Bibliographic Details
Main Authors:	Cheng-Kuei Wu, Man-Ting Wei, Hung-Chang Wu, Cheng-Lin Wu, Cheng-Ju Wu, Hungjiun Liaw, Wen-Pin Su
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-09-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-20788-2

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