High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice
Aggressive behavior is one of congenital social behaviors in many species, which could be promoted by social neglect or isolation in the early stages of life. Many brain regions including the medial prefrontal cortex (mPFC), medial amygdala (MeA) and ventromedial hypothalamus (VMH) are demonstrated...
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MDPI AG
2022-11-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/11/1682 |
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| author | Jing Yang Yansu Liu Yanzhu Fan Di Shen Jiangyan Shen Guangzhan Fang |
| author_facet | Jing Yang Yansu Liu Yanzhu Fan Di Shen Jiangyan Shen Guangzhan Fang |
| author_sort | Jing Yang |
| collection | DOAJ |
| description | Aggressive behavior is one of congenital social behaviors in many species, which could be promoted by social neglect or isolation in the early stages of life. Many brain regions including the medial prefrontal cortex (mPFC), medial amygdala (MeA) and ventromedial hypothalamus (VMH) are demonstrated to relate to aggressive behavior; however, the dynamic patterns of neural activities during the occurrence of this behavior remain unclear. In this study, 21-day-old male CD-1 mice were reared in social isolation conditions and cohousing conditions for two weeks. Aggressive behaviors of each subject were estimated by the resident–intruder test. Simultaneously, the local field potentials of mPFC, MeA and VMH were recorded for exploring differences in the relative power spectra of different oscillations when aggressive behaviors occurred. The results showed that the following: (1) Compared with the cohousing mice, the socially isolated mice exhibited more aggression. (2) Regardless of “time condition” (pre-, during- and post- attack), the relative power spectra of beta band in the cohousing mice were significantly greater than those in the socially isolated mice, and inversely, the relative power spectra of gamma band in the cohousing mice were significantly smaller than those in the socially isolated mice. (3) The bilateral mPFC exhibited significantly smaller beta power spectra but greater gamma power spectra compared with other brain areas regardless of rearing patterns. (4) For the right VMH of the socially isolated mice, the relative power spectra of the gamma band during attacks were significantly greater than those before attack. These results suggest that aggressive behaviors in mice could be shaped by rearing patterns and that high-frequency oscillations (beta and gamma bands) may engage in mediating aggressive behaviors in mice. |
| first_indexed | 2024-03-09T18:27:37Z |
| format | Article |
| id | doaj.art-a606e97ef16e420ab99f198eef1d7b09 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T18:27:37Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a606e97ef16e420ab99f198eef1d7b092023-11-24T07:45:33ZengMDPI AGBiology2079-77372022-11-011111168210.3390/biology11111682High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in MiceJing Yang0Yansu Liu1Yanzhu Fan2Di Shen3Jiangyan Shen4Guangzhan Fang5Chengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin Nan Road, Chengdu 610041, ChinaSichuan Nursing Vocational College, No. 173 Longdu Nan Road, Chengdu 610100, ChinaChengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin Nan Road, Chengdu 610041, ChinaChengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin Nan Road, Chengdu 610041, ChinaChengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin Nan Road, Chengdu 610041, ChinaChengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin Nan Road, Chengdu 610041, ChinaAggressive behavior is one of congenital social behaviors in many species, which could be promoted by social neglect or isolation in the early stages of life. Many brain regions including the medial prefrontal cortex (mPFC), medial amygdala (MeA) and ventromedial hypothalamus (VMH) are demonstrated to relate to aggressive behavior; however, the dynamic patterns of neural activities during the occurrence of this behavior remain unclear. In this study, 21-day-old male CD-1 mice were reared in social isolation conditions and cohousing conditions for two weeks. Aggressive behaviors of each subject were estimated by the resident–intruder test. Simultaneously, the local field potentials of mPFC, MeA and VMH were recorded for exploring differences in the relative power spectra of different oscillations when aggressive behaviors occurred. The results showed that the following: (1) Compared with the cohousing mice, the socially isolated mice exhibited more aggression. (2) Regardless of “time condition” (pre-, during- and post- attack), the relative power spectra of beta band in the cohousing mice were significantly greater than those in the socially isolated mice, and inversely, the relative power spectra of gamma band in the cohousing mice were significantly smaller than those in the socially isolated mice. (3) The bilateral mPFC exhibited significantly smaller beta power spectra but greater gamma power spectra compared with other brain areas regardless of rearing patterns. (4) For the right VMH of the socially isolated mice, the relative power spectra of the gamma band during attacks were significantly greater than those before attack. These results suggest that aggressive behaviors in mice could be shaped by rearing patterns and that high-frequency oscillations (beta and gamma bands) may engage in mediating aggressive behaviors in mice.https://www.mdpi.com/2079-7737/11/11/1682aggressive behaviorrearing patternlocal field potentialrelative power spectramice |
| spellingShingle | Jing Yang Yansu Liu Yanzhu Fan Di Shen Jiangyan Shen Guangzhan Fang High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice Biology aggressive behavior rearing pattern local field potential relative power spectra mice |
| title | High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice |
| title_full | High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice |
| title_fullStr | High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice |
| title_full_unstemmed | High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice |
| title_short | High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice |
| title_sort | high frequency local field potential oscillations may modulate aggressive behaviors in mice |
| topic | aggressive behavior rearing pattern local field potential relative power spectra mice |
| url | https://www.mdpi.com/2079-7737/11/11/1682 |
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