Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice

Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice

Abstract Background Intracellular deposition of alpha‐synuclein (α‐syn) as Lewy bodies and Lewy neurites is a central event in the pathogenesis of Parkinson's disease (PD) and other α‐synucleinopathies. Transgenic mouse models overexpressing human α‐syn, are useful research tools in preclinical...

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Bibliographic Details
Main Authors: Agata Aniszewska, Joakim Bergström, Martin Ingelsson, Sara Ekmark‐Lewén
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Brain and Behavior
Subjects:
alpha‐synuclein
behavioral test
ethology
Parkinson´s disease
transgenic mouse models
translational research
Online Access:https://doi.org/10.1002/brb3.2628

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