Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease
Abstract Introduction Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). Methods Sevent...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12356 |
| _version_ | 1797949002266705920 |
|---|---|
| author | Moto Nakaya Noriko Sato Hiroshi Matsuda Norihide Maikusa Yoko Shigemoto Daichi Sone Tensho Yamao Masayo Ogawa Yukio Kimura Emiko Chiba Masahiro Ohnishi Koichi Kato Kyoji Okita Tadashi Tsukamoto Yuma Yokoi Masuhiro Sakata Osamu Abe |
| author_facet | Moto Nakaya Noriko Sato Hiroshi Matsuda Norihide Maikusa Yoko Shigemoto Daichi Sone Tensho Yamao Masayo Ogawa Yukio Kimura Emiko Chiba Masahiro Ohnishi Koichi Kato Kyoji Okita Tadashi Tsukamoto Yuma Yokoi Masuhiro Sakata Osamu Abe |
| author_sort | Moto Nakaya |
| collection | DOAJ |
| description | Abstract Introduction Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). Methods Seventy‐one participants underwent multi‐shell diffusion MRI, 18F‐THK5351 PET, 11C‐Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD‐spectrum group (AD‐S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores. Results In AD‐S group, there was a significant positive correlation between FW and 18F‐THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between 18F‐THK5351 and cognitive function in the same regions. Discussion FW imaging could be a biomarker for tau in AD alongside clinical correlations. |
| first_indexed | 2024-04-10T21:52:27Z |
| format | Article |
| id | doaj.art-a60959aa3ffc4cc2bc1f5b8ad5cc253d |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:52:27Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-a60959aa3ffc4cc2bc1f5b8ad5cc253d2023-01-18T11:41:04ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12356Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's diseaseMoto Nakaya0Noriko Sato1Hiroshi Matsuda2Norihide Maikusa3Yoko Shigemoto4Daichi Sone5Tensho Yamao6Masayo Ogawa7Yukio Kimura8Emiko Chiba9Masahiro Ohnishi10Koichi Kato11Kyoji Okita12Tadashi Tsukamoto13Yuma Yokoi14Masuhiro Sakata15Osamu Abe16Department of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Psychiatry The Jikei University School of Medicine Tokyo JapanDepartment of Radiological Sciences School of Health Sciences Fukushima Medical University Fukushima JapanIntegrative Brain Imaging Center National Center of Neurology and Psychiatry Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanDepartment of Radiology National Center Hospital of Neurology and Psychiatry Ogawa‐Higashi Kodaira Tokyo JapanIntegrative Brain Imaging Center National Center of Neurology and Psychiatry Tokyo JapanIntegrative Brain Imaging Center National Center of Neurology and Psychiatry Tokyo JapanDepartment of Neurology National Center of Neurology and Psychiatry Kodaira Tokyo JapanDepartment of Psychiatry National Center of Neurology and Psychiatry Kodaira Tokyo JapanDepartment of Psychiatry National Center of Neurology and Psychiatry Kodaira Tokyo JapanDepartment of Radiology Graduate School of Medicine University of Tokyo Hongo Bunkyo‐ku Tokyo JapanAbstract Introduction Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). Methods Seventy‐one participants underwent multi‐shell diffusion MRI, 18F‐THK5351 PET, 11C‐Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD‐spectrum group (AD‐S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores. Results In AD‐S group, there was a significant positive correlation between FW and 18F‐THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between 18F‐THK5351 and cognitive function in the same regions. Discussion FW imaging could be a biomarker for tau in AD alongside clinical correlations.https://doi.org/10.1002/trc2.12356Alzheimer's diseasefree‐water imagingCentiloid scaleamyloidtau |
| spellingShingle | Moto Nakaya Noriko Sato Hiroshi Matsuda Norihide Maikusa Yoko Shigemoto Daichi Sone Tensho Yamao Masayo Ogawa Yukio Kimura Emiko Chiba Masahiro Ohnishi Koichi Kato Kyoji Okita Tadashi Tsukamoto Yuma Yokoi Masuhiro Sakata Osamu Abe Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease free‐water imaging Centiloid scale amyloid tau |
| title | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
| title_full | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
| title_fullStr | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
| title_full_unstemmed | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
| title_short | Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease |
| title_sort | free water derived by multi shell diffusion mri reflects tau neuroinflammatory pathology in alzheimer s disease |
| topic | Alzheimer's disease free‐water imaging Centiloid scale amyloid tau |
| url | https://doi.org/10.1002/trc2.12356 |
| work_keys_str_mv | AT motonakaya freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT norikosato freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT hiroshimatsuda freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT norihidemaikusa freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT yokoshigemoto freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT daichisone freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT tenshoyamao freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT masayoogawa freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT yukiokimura freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT emikochiba freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT masahiroohnishi freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT koichikato freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT kyojiokita freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT tadashitsukamoto freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT yumayokoi freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT masuhirosakata freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease AT osamuabe freewaterderivedbymultishelldiffusionmrireflectstauneuroinflammatorypathologyinalzheimersdisease |