Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits
BackgroundElectric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2023.1214959/full |
| _version_ | 1797691165007413248 |
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| author | Jennifer Y. Cho Sybren Van Hoornweder Christopher T. Sege Michael U. Antonucci Lisa M. McTeague Lisa M. McTeague Kevin A. Caulfield Kevin A. Caulfield |
| author_facet | Jennifer Y. Cho Sybren Van Hoornweder Christopher T. Sege Michael U. Antonucci Lisa M. McTeague Lisa M. McTeague Kevin A. Caulfield Kevin A. Caulfield |
| author_sort | Jennifer Y. Cho |
| collection | DOAJ |
| description | BackgroundElectric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested whether E-field models in template MNI-152 and Ernie scans can reliably approximate group-level E-fields induced in N = 195 individuals across 5 diagnoses (healthy, alcohol use disorder, tobacco use disorder, anxiety, depression).MethodsWe computed 788 E-field models using the CHARM–SimNIBS 4.0.0 pipeline with 4 E-field models per participant (motor and prefrontal targets for TMS and tES). We additionally calculated permutation analyses to determine the point of stability of E-fields to assess whether the 152 brains represented in the MNI-152 template is sufficient.ResultsGroup-level E-fields did not significantly differ between the individual vs. MNI-152 template and Ernie scans for any stimulation modality or location (p > 0.05). However, TMS-induced E-field magnitudes significantly varied by diagnosis; individuals with generalized anxiety had significantly higher prefrontal and motor E-field magnitudes than healthy controls and those with alcohol use disorder and depression (p < 0.001). The point of stability for group-level E-field magnitudes ranged from 42 (motor tES) to 52 participants (prefrontal TMS).ConclusionMNI-152 and Ernie models reliably estimate group-average TMS and tES-induced E-fields transdiagnostically. The MNI-152 template includes sufficient scans to control for interindividual anatomical differences (i.e., above the point of stability). Taken together, using the MNI-152 and Ernie brains to approximate group-level E-fields is a valid and reliable approach. |
| first_indexed | 2024-03-12T02:10:23Z |
| format | Article |
| id | doaj.art-a60c2753dd474d359e3d6e60aef31d74 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-03-12T02:10:23Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-a60c2753dd474d359e3d6e60aef31d742023-09-06T14:11:06ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102023-09-011710.3389/fncir.2023.12149591214959Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuitsJennifer Y. Cho0Sybren Van Hoornweder1Christopher T. Sege2Michael U. Antonucci3Lisa M. McTeague4Lisa M. McTeague5Kevin A. Caulfield6Kevin A. Caulfield7Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United StatesFaculty of Rehabilitation Sciences, REVAL–Rehabilitation Research Center, Hasselt University, Diepenbeek, BelgiumDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, United StatesRalph H. Johnson VA Medical Center, Charleston, SC, United StatesDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, United StatesBackgroundElectric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested whether E-field models in template MNI-152 and Ernie scans can reliably approximate group-level E-fields induced in N = 195 individuals across 5 diagnoses (healthy, alcohol use disorder, tobacco use disorder, anxiety, depression).MethodsWe computed 788 E-field models using the CHARM–SimNIBS 4.0.0 pipeline with 4 E-field models per participant (motor and prefrontal targets for TMS and tES). We additionally calculated permutation analyses to determine the point of stability of E-fields to assess whether the 152 brains represented in the MNI-152 template is sufficient.ResultsGroup-level E-fields did not significantly differ between the individual vs. MNI-152 template and Ernie scans for any stimulation modality or location (p > 0.05). However, TMS-induced E-field magnitudes significantly varied by diagnosis; individuals with generalized anxiety had significantly higher prefrontal and motor E-field magnitudes than healthy controls and those with alcohol use disorder and depression (p < 0.001). The point of stability for group-level E-field magnitudes ranged from 42 (motor tES) to 52 participants (prefrontal TMS).ConclusionMNI-152 and Ernie models reliably estimate group-average TMS and tES-induced E-fields transdiagnostically. The MNI-152 template includes sufficient scans to control for interindividual anatomical differences (i.e., above the point of stability). Taken together, using the MNI-152 and Ernie brains to approximate group-level E-fields is a valid and reliable approach.https://www.frontiersin.org/articles/10.3389/fncir.2023.1214959/fullTMStEStDCSnon-invasive brain stimulationelectric field (E-field) modelingfinite element method (FEM) |
| spellingShingle | Jennifer Y. Cho Sybren Van Hoornweder Christopher T. Sege Michael U. Antonucci Lisa M. McTeague Lisa M. McTeague Kevin A. Caulfield Kevin A. Caulfield Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits Frontiers in Neural Circuits TMS tES tDCS non-invasive brain stimulation electric field (E-field) modeling finite element method (FEM) |
| title | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits |
| title_full | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits |
| title_fullStr | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits |
| title_full_unstemmed | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits |
| title_short | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits |
| title_sort | template mri scans reliably approximate individual and group level tes and tms electric fields induced in motor and prefrontal circuits |
| topic | TMS tES tDCS non-invasive brain stimulation electric field (E-field) modeling finite element method (FEM) |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2023.1214959/full |
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