Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period
Background: Ischemic mitral regurgitation (IMR) is a common complication of acute ST-elevation myocardial infarction (STEMI). Little is known regarding the impact of IMR over a long period of follow up.Methods: Of 3,208 consecutive STEMI patients from a prospective registry, full echocardiographic i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.796041/full |
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| author | Leor Perl Leor Perl Tamir Bental Tamir Bental Katia Orvin Katia Orvin Hana Vaknin-Assa Hana Vaknin-Assa Gabriel Greenberg Gabriel Greenberg Pablo Codner Pablo Codner Yaron Shapira Yaron Shapira Mordehay Vaturi Mordehay Vaturi Alexander Sagie Alexander Sagie Ran Kornowski Ran Kornowski |
| author_facet | Leor Perl Leor Perl Tamir Bental Tamir Bental Katia Orvin Katia Orvin Hana Vaknin-Assa Hana Vaknin-Assa Gabriel Greenberg Gabriel Greenberg Pablo Codner Pablo Codner Yaron Shapira Yaron Shapira Mordehay Vaturi Mordehay Vaturi Alexander Sagie Alexander Sagie Ran Kornowski Ran Kornowski |
| author_sort | Leor Perl |
| collection | DOAJ |
| description | Background: Ischemic mitral regurgitation (IMR) is a common complication of acute ST-elevation myocardial infarction (STEMI). Little is known regarding the impact of IMR over a long period of follow up.Methods: Of 3,208 consecutive STEMI patients from a prospective registry, full echocardiographic information was available for 2,985 patients between the years 2000 and 2020. We compared the two decades- 2001 to 2010 and 2011 to 2020, and assessed for the presence of IMR at baseline, 3 (range 2–6) months and 12 (range 10–14) months after the index event.Results: One thousand six hundred and sixty six patients were included in the first decade, 1,319 in the second. Mean patient age was 61.3 ± 12.3 years, 21.1% female patients in the first decade vs. 60.9 ± 12.0 years and 22.2% female in the second (p = 0.40 and p = 0.212, respectively). Rates of moderate IMR or above during the index admission were 17.2% in the first period and 9.3% in the second one (p < 0.001). After 3 months, the rate of IMR was 48.5% for those who suffered from IMR at baseline, vs. 9.5% for those without IMR at baseline (HR- 4.2, p < 0.001). Death rates for those with moderate IMR or above were 14.7% and 17.8% after 1 and 2 years, respectively, vs. 7.3 and 9.6% for those without (p < 0.001 for both). IMR was associated with 1 year mortality in multivariate analysis (HR-1.37; 1.09–2.20, p = 0.009), as well as in propensity score matched analysis (HR 1.29; CI: 1.07–1.91; p < 0.001).Conclusions: IMR is a common complication following acute STEMI, impacting prognosis. Rates of IMR have declined significantly over the years. |
| first_indexed | 2024-12-18T05:26:29Z |
| format | Article |
| id | doaj.art-a60fa69c7449472ba85183d0e304c3cf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-18T05:26:29Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-a60fa69c7449472ba85183d0e304c3cf2022-12-21T21:19:31ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.796041796041Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year PeriodLeor Perl0Leor Perl1Tamir Bental2Tamir Bental3Katia Orvin4Katia Orvin5Hana Vaknin-Assa6Hana Vaknin-Assa7Gabriel Greenberg8Gabriel Greenberg9Pablo Codner10Pablo Codner11Yaron Shapira12Yaron Shapira13Mordehay Vaturi14Mordehay Vaturi15Alexander Sagie16Alexander Sagie17Ran Kornowski18Ran Kornowski19Department of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Cardiology, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelAffiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelBackground: Ischemic mitral regurgitation (IMR) is a common complication of acute ST-elevation myocardial infarction (STEMI). Little is known regarding the impact of IMR over a long period of follow up.Methods: Of 3,208 consecutive STEMI patients from a prospective registry, full echocardiographic information was available for 2,985 patients between the years 2000 and 2020. We compared the two decades- 2001 to 2010 and 2011 to 2020, and assessed for the presence of IMR at baseline, 3 (range 2–6) months and 12 (range 10–14) months after the index event.Results: One thousand six hundred and sixty six patients were included in the first decade, 1,319 in the second. Mean patient age was 61.3 ± 12.3 years, 21.1% female patients in the first decade vs. 60.9 ± 12.0 years and 22.2% female in the second (p = 0.40 and p = 0.212, respectively). Rates of moderate IMR or above during the index admission were 17.2% in the first period and 9.3% in the second one (p < 0.001). After 3 months, the rate of IMR was 48.5% for those who suffered from IMR at baseline, vs. 9.5% for those without IMR at baseline (HR- 4.2, p < 0.001). Death rates for those with moderate IMR or above were 14.7% and 17.8% after 1 and 2 years, respectively, vs. 7.3 and 9.6% for those without (p < 0.001 for both). IMR was associated with 1 year mortality in multivariate analysis (HR-1.37; 1.09–2.20, p = 0.009), as well as in propensity score matched analysis (HR 1.29; CI: 1.07–1.91; p < 0.001).Conclusions: IMR is a common complication following acute STEMI, impacting prognosis. Rates of IMR have declined significantly over the years.https://www.frontiersin.org/articles/10.3389/fcvm.2021.796041/fullischemic mitral regurgitationmyocardial infarctionprimary percutaneous coronaryremodelingST-segment elevation myocardial infarction |
| spellingShingle | Leor Perl Leor Perl Tamir Bental Tamir Bental Katia Orvin Katia Orvin Hana Vaknin-Assa Hana Vaknin-Assa Gabriel Greenberg Gabriel Greenberg Pablo Codner Pablo Codner Yaron Shapira Yaron Shapira Mordehay Vaturi Mordehay Vaturi Alexander Sagie Alexander Sagie Ran Kornowski Ran Kornowski Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period Frontiers in Cardiovascular Medicine ischemic mitral regurgitation myocardial infarction primary percutaneous coronary remodeling ST-segment elevation myocardial infarction |
| title | Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period |
| title_full | Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period |
| title_fullStr | Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period |
| title_full_unstemmed | Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period |
| title_short | Trends in Ischemic Mitral Regurgitation Following ST-Elevation Myocardial Infarction Over a 20-Year Period |
| title_sort | trends in ischemic mitral regurgitation following st elevation myocardial infarction over a 20 year period |
| topic | ischemic mitral regurgitation myocardial infarction primary percutaneous coronary remodeling ST-segment elevation myocardial infarction |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.796041/full |
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