Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases
The Beijing/W genotype is one of the major molecular families of <i>Mycobacterium tuberculosis</i> complex (MTBC), responsible for approximately 50% of tuberculosis (TB) cases in Far East Asia and at least 25% of TB cases globally. Studies have revealed that the Beijing genotype family i...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1699 |
| _version_ | 1797406789138907136 |
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| author | Monika Kozińska Marcin Skowroński Paweł Gruszczyński Ewa Augustynowicz-Kopeć |
| author_facet | Monika Kozińska Marcin Skowroński Paweł Gruszczyński Ewa Augustynowicz-Kopeć |
| author_sort | Monika Kozińska |
| collection | DOAJ |
| description | The Beijing/W genotype is one of the major molecular families of <i>Mycobacterium tuberculosis</i> complex (MTBC), responsible for approximately 50% of tuberculosis (TB) cases in Far East Asia and at least 25% of TB cases globally. Studies have revealed that the Beijing genotype family is associated with a more severe clinical course of TB, increased ability to spread compared to other genotypes, and an unpredictable response to treatment. Based on the profile of spacers 35–43 in the Direct Repeat (DR) locus of the MTBC genome determined by spoligotyping, classical (typical) and modern (Beijing-like) clones can be identified within the Beijing family. While the modern and ancient Beijing strains appear to be closely related at the genetic level, there are marked differences in their drug resistance, as well as their ability to spread and cause disease. This paper presents two cases of drug-resistant tuberculosis caused by rare mycobacteria from the Beijing family: the Beijing 265 and Beijing 541 subtypes. The genotypes of isolated strains were linked with the clinical course of TB, and an attempt was made to initially assess whether the Beijing subtype can determine treatment outcomes in patients. |
| first_indexed | 2024-03-09T03:31:42Z |
| format | Article |
| id | doaj.art-a61280cb1c9549cc9d9486f6a8cca77d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:31:42Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a61280cb1c9549cc9d9486f6a8cca77d2023-12-03T14:55:06ZengMDPI AGDiagnostics2075-44182022-07-01127169910.3390/diagnostics12071699Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB CasesMonika Kozińska0Marcin Skowroński1Paweł Gruszczyński2Ewa Augustynowicz-Kopeć3Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Plocka 26, 01-138 Warsaw, PolandWielkopolska Pulmonology and Thoracic Surgery Centre of Eugenia and Janusz Zeyland, Szamarzewskiego 62, 60-569 Poznań, PolandWielkopolska Pulmonology and Thoracic Surgery Centre of Eugenia and Janusz Zeyland, Szamarzewskiego 62, 60-569 Poznań, PolandDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Plocka 26, 01-138 Warsaw, PolandThe Beijing/W genotype is one of the major molecular families of <i>Mycobacterium tuberculosis</i> complex (MTBC), responsible for approximately 50% of tuberculosis (TB) cases in Far East Asia and at least 25% of TB cases globally. Studies have revealed that the Beijing genotype family is associated with a more severe clinical course of TB, increased ability to spread compared to other genotypes, and an unpredictable response to treatment. Based on the profile of spacers 35–43 in the Direct Repeat (DR) locus of the MTBC genome determined by spoligotyping, classical (typical) and modern (Beijing-like) clones can be identified within the Beijing family. While the modern and ancient Beijing strains appear to be closely related at the genetic level, there are marked differences in their drug resistance, as well as their ability to spread and cause disease. This paper presents two cases of drug-resistant tuberculosis caused by rare mycobacteria from the Beijing family: the Beijing 265 and Beijing 541 subtypes. The genotypes of isolated strains were linked with the clinical course of TB, and an attempt was made to initially assess whether the Beijing subtype can determine treatment outcomes in patients.https://www.mdpi.com/2075-4418/12/7/1699tuberculosisdrug resistance<i>Mycobacterium tuberculosis</i>Beijing-TBBeijing-like genotype |
| spellingShingle | Monika Kozińska Marcin Skowroński Paweł Gruszczyński Ewa Augustynowicz-Kopeć Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases Diagnostics tuberculosis drug resistance <i>Mycobacterium tuberculosis</i> Beijing-TB Beijing-like genotype |
| title | Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases |
| title_full | Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases |
| title_fullStr | Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases |
| title_full_unstemmed | Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases |
| title_short | Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases |
| title_sort | multidrug resistant tuberculosis diagnostic procedures and treatment of two beijing like tb cases |
| topic | tuberculosis drug resistance <i>Mycobacterium tuberculosis</i> Beijing-TB Beijing-like genotype |
| url | https://www.mdpi.com/2075-4418/12/7/1699 |
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