Polygene Risk Scores
This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects. Although their purely predictive/correlational u...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2023-07-01
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| Series: | Philosophy of Medicine |
| Subjects: | |
| Online Access: | https://philmed.pitt.edu/philmed/article/view/156 |
| _version_ | 1797786860101042176 |
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| author | James Woodward Kenneth Kendler |
| author_facet | James Woodward Kenneth Kendler |
| author_sort | James Woodward |
| collection | DOAJ |
| description | This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects. Although their purely predictive/correlational use is important, it is this tracking feature that contributes to their potential usefulness in other applications, such as genetic dissection, and their use as controls, which allow us, indirectly, to "see" more clearly the role of environmental variables.
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| first_indexed | 2024-03-13T01:13:49Z |
| format | Article |
| id | doaj.art-a6132dc50fdf490cb2c0e511d525669e |
| institution | Directory Open Access Journal |
| issn | 2692-3963 |
| language | English |
| last_indexed | 2024-03-13T01:13:49Z |
| publishDate | 2023-07-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Philosophy of Medicine |
| spelling | doaj.art-a6132dc50fdf490cb2c0e511d525669e2023-07-05T14:50:07ZengUniversity Library System, University of PittsburghPhilosophy of Medicine2692-39632023-07-014110.5195/pom.2023.156Polygene Risk ScoresJames Woodward0Kenneth Kendler1Emeritus, Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PAVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VAThis paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects. Although their purely predictive/correlational use is important, it is this tracking feature that contributes to their potential usefulness in other applications, such as genetic dissection, and their use as controls, which allow us, indirectly, to "see" more clearly the role of environmental variables. https://philmed.pitt.edu/philmed/article/view/156Polygene risk scoresgenetic causation |
| spellingShingle | James Woodward Kenneth Kendler Polygene Risk Scores Philosophy of Medicine Polygene risk scores genetic causation |
| title | Polygene Risk Scores |
| title_full | Polygene Risk Scores |
| title_fullStr | Polygene Risk Scores |
| title_full_unstemmed | Polygene Risk Scores |
| title_short | Polygene Risk Scores |
| title_sort | polygene risk scores |
| topic | Polygene risk scores genetic causation |
| url | https://philmed.pitt.edu/philmed/article/view/156 |
| work_keys_str_mv | AT jameswoodward polygeneriskscores AT kennethkendler polygeneriskscores |