miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knoc...

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Bibliographic Details
Main Authors: Matteo Forloni, Shaillay Kumar Dogra, Yuying Dong, Darryl Conte Jr, Jianhong Ou, Lihua Julie Zhu, April Deng, Meera Mahalingam, Michael R Green, Narendra Wajapeyee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
miRNA
BRAF
NRAS
melanoma
Online Access:https://elifesciences.org/articles/01460

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