Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study
Abstract Background Distorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients’ perceptions of depression severity, and predict chronicity and treatment response. This study aimed to investigate whether distorted thoughts mediate depressive symptoms in MDD over a 6-mon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-023-02178-y |
| _version_ | 1797556317410295808 |
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| author | Adriana Munhoz Carneiro Danilo Assis Pereira Fernando Fernandes Makilim Nunes Baptista André Russowsky Brunoni Ricardo Alberto Moreno |
| author_facet | Adriana Munhoz Carneiro Danilo Assis Pereira Fernando Fernandes Makilim Nunes Baptista André Russowsky Brunoni Ricardo Alberto Moreno |
| author_sort | Adriana Munhoz Carneiro |
| collection | DOAJ |
| description | Abstract Background Distorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients’ perceptions of depression severity, and predict chronicity and treatment response. This study aimed to investigate whether distorted thoughts mediate depressive symptoms in MDD over a 6-month period. Method These are secondary results from a study that followed 119 patients diagnosed with moderate to severe MDD for 6 months. Diagnoses were confirmed by the Structured Interview for DSM-IV (SCID-CV). The analysis was composed of results from the Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS), the second edition of the Beck Depression Inventory (BDI-II), and the Depression Thoughts Scale (DTS) collected at weeks 1, 8, 12 and 24. Results Results showed that the DTS mediated the relationship between depressive symptoms experienced approximately 3 months after starting antidepressant treatment. Conclusion Cognitive distortions were linked as a mediator to depressive symptoms, highlighting the importance of early psychological interventions in patients with MDD who exhibit these distortions. Trial registration NCT02268487. |
| first_indexed | 2024-03-10T17:00:08Z |
| format | Article |
| id | doaj.art-a613d34c8f784431a4a56bfd9e1cfaa7 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-03-10T17:00:08Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-a613d34c8f784431a4a56bfd9e1cfaa72023-11-20T11:00:10ZengBMCHealth and Quality of Life Outcomes1477-75252023-08-012111810.1186/s12955-023-02178-yDistorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal studyAdriana Munhoz Carneiro0Danilo Assis Pereira1Fernando Fernandes2Makilim Nunes Baptista3André Russowsky Brunoni4Ricardo Alberto Moreno5Mood Disorders Unit, Faculty of Medicine FMUSP, University of Sao PauloIndependent ConsultantMood Disorders Unit, Faculty of Medicine FMUSP, University of Sao PauloLaboratory of Psychometric Evaluation in Mental Health -LAPSAM III - São Francisco UniversityDepartment of Internal Medicine, Faculty of Medicine FMUSP, University of Sao PauloMood Disorders Unit, Faculty of Medicine FMUSP, University of Sao PauloAbstract Background Distorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients’ perceptions of depression severity, and predict chronicity and treatment response. This study aimed to investigate whether distorted thoughts mediate depressive symptoms in MDD over a 6-month period. Method These are secondary results from a study that followed 119 patients diagnosed with moderate to severe MDD for 6 months. Diagnoses were confirmed by the Structured Interview for DSM-IV (SCID-CV). The analysis was composed of results from the Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS), the second edition of the Beck Depression Inventory (BDI-II), and the Depression Thoughts Scale (DTS) collected at weeks 1, 8, 12 and 24. Results Results showed that the DTS mediated the relationship between depressive symptoms experienced approximately 3 months after starting antidepressant treatment. Conclusion Cognitive distortions were linked as a mediator to depressive symptoms, highlighting the importance of early psychological interventions in patients with MDD who exhibit these distortions. Trial registration NCT02268487.https://doi.org/10.1186/s12955-023-02178-yDepressive disorderCognitive distortionsThinkingDysfunctional thinkingDepressionMediation |
| spellingShingle | Adriana Munhoz Carneiro Danilo Assis Pereira Fernando Fernandes Makilim Nunes Baptista André Russowsky Brunoni Ricardo Alberto Moreno Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study Health and Quality of Life Outcomes Depressive disorder Cognitive distortions Thinking Dysfunctional thinking Depression Mediation |
| title | Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study |
| title_full | Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study |
| title_fullStr | Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study |
| title_full_unstemmed | Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study |
| title_short | Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study |
| title_sort | distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder a longitudinal study |
| topic | Depressive disorder Cognitive distortions Thinking Dysfunctional thinking Depression Mediation |
| url | https://doi.org/10.1186/s12955-023-02178-y |
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