Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women
The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grad...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2018-10-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/7/9/EC-18-0158.xml |
| _version_ | 1818048300515852288 |
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| author | María J Gómora Flavia Morales-Vásquez Enrique Pedernera Delia Perez-Montiel Horacio López-Basave Antonio R Villa Azucena Hernández-Martínez Esteban Mena Carmen Mendez |
| author_facet | María J Gómora Flavia Morales-Vásquez Enrique Pedernera Delia Perez-Montiel Horacio López-Basave Antonio R Villa Azucena Hernández-Martínez Esteban Mena Carmen Mendez |
| author_sort | María J Gómora |
| collection | DOAJ |
| description | The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER− PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium shows that the expression of only ER is associated to a reduced proliferation index in endometrioid carcinoma. Steroid hormone receptor expression and co-expression could help characterize ovarian carcinoma. |
| first_indexed | 2024-12-10T10:19:30Z |
| format | Article |
| id | doaj.art-a61416b2af764873b63d9d3c4371a29c |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-10T10:19:30Z |
| publishDate | 2018-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-a61416b2af764873b63d9d3c4371a29c2022-12-22T01:52:55ZengBioscientificaEndocrine Connections2049-36142049-36142018-10-017910061012https://doi.org/10.1530/EC-18-0158Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican womenMaría J Gómora0Flavia Morales-Vásquez1Enrique Pedernera2Delia Perez-Montiel3Horacio López-Basave4Antonio R Villa5Azucena Hernández-Martínez6Esteban Mena7Carmen Mendez8Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, MexicoDepartamento de Oncología Médica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, MexicoDepartamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, MexicoDepartamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, MexicoDepartamento de Cirugía Oncológica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, MexicoDivisión de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, MexicoHospital Militar de Especialidades de la Mujer y Neonatología, Secretaría de la Defensa Nacional, CdMx, MexicoUnidad de Apoyo Académico, Secretaría General, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, MexicoDepartamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, MexicoThe significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER− PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium shows that the expression of only ER is associated to a reduced proliferation index in endometrioid carcinoma. Steroid hormone receptor expression and co-expression could help characterize ovarian carcinoma.https://ec.bioscientifica.com/view/journals/ec/7/9/EC-18-0158.xmlovarian cancersteroid hormoneshormone receptorsproliferation indexovarian carcinoma |
| spellingShingle | María J Gómora Flavia Morales-Vásquez Enrique Pedernera Delia Perez-Montiel Horacio López-Basave Antonio R Villa Azucena Hernández-Martínez Esteban Mena Carmen Mendez Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women Endocrine Connections ovarian cancer steroid hormones hormone receptors proliferation index ovarian carcinoma |
| title | Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women |
| title_full | Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women |
| title_fullStr | Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women |
| title_full_unstemmed | Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women |
| title_short | Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women |
| title_sort | sexual steroid hormone receptors profiles of ovarian carcinoma in mexican women |
| topic | ovarian cancer steroid hormones hormone receptors proliferation index ovarian carcinoma |
| url | https://ec.bioscientifica.com/view/journals/ec/7/9/EC-18-0158.xml |
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