Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery
Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m<sup>2</sup>/g. The doxorubicin loading efficiency was 38.2...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/13/8/1998 |
| _version_ | 1797569730735767552 |
|---|---|
| author | Jason Lin Chuanqi Peng Sanjana Ravi A. K. M. Nur Alam Siddiki Jie Zheng Kenneth J. Balkus |
| author_facet | Jason Lin Chuanqi Peng Sanjana Ravi A. K. M. Nur Alam Siddiki Jie Zheng Kenneth J. Balkus |
| author_sort | Jason Lin |
| collection | DOAJ |
| description | Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m<sup>2</sup>/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery. |
| first_indexed | 2024-03-10T20:14:41Z |
| format | Article |
| id | doaj.art-a616c51eb7b543ed96ac4794d188aacc |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T20:14:41Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-a616c51eb7b543ed96ac4794d188aacc2023-11-19T22:38:49ZengMDPI AGMaterials1996-19442020-04-01138199810.3390/ma13081998Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug DeliveryJason Lin0Chuanqi Peng1Sanjana Ravi2A. K. M. Nur Alam Siddiki3Jie Zheng4Kenneth J. Balkus5Department of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USADepartment of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USADepartment of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USADepartment of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USADepartment of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USADepartment of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USABiphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m<sup>2</sup>/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.https://www.mdpi.com/1996-1944/13/8/1998wrinkled mesoporous silicadrug deliverypH selectivedoxorubicin |
| spellingShingle | Jason Lin Chuanqi Peng Sanjana Ravi A. K. M. Nur Alam Siddiki Jie Zheng Kenneth J. Balkus Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery Materials wrinkled mesoporous silica drug delivery pH selective doxorubicin |
| title | Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery |
| title_full | Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery |
| title_fullStr | Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery |
| title_full_unstemmed | Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery |
| title_short | Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery |
| title_sort | biphenyl wrinkled mesoporous silica nanoparticles for ph responsive doxorubicin drug delivery |
| topic | wrinkled mesoporous silica drug delivery pH selective doxorubicin |
| url | https://www.mdpi.com/1996-1944/13/8/1998 |
| work_keys_str_mv | AT jasonlin biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery AT chuanqipeng biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery AT sanjanaravi biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery AT akmnuralamsiddiki biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery AT jiezheng biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery AT kennethjbalkus biphenylwrinkledmesoporoussilicananoparticlesforphresponsivedoxorubicindrugdelivery |