| Summary: | <i>Maytenus dhofarensis</i> Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of <i>M. dhofarensis</i> afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (<b>1</b>), lupanyl myristoate (<b>2</b>) and lignanolactone (<b>3</b>). Compounds (<b>1</b>–<b>3</b>) are new isolates from <i>M. dhofarensis</i>. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds <b>1</b> and <b>3</b> were deduced from density function theory (DFT) calculations and NMR experiments. Compound <b>1</b> was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound <b>3</b> inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.
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