Gasdermin D pore-forming activity is redox-sensitive

Gasdermin D pore-forming activity is redox-sensitive

Summary: Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may be multifaceted. Herein, we report that the protein gasdermin D (GSDMD...

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Bibliographic Details
Main Authors: Pascal Devant, Elvira Boršić, Elsy M. Ngwa, Haopeng Xiao, Edward T. Chouchani, Jay R. Thiagarajah, Iva Hafner-Bratkovič, Charles L. Evavold, Jonathan C. Kagan
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000190

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