Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics
Follicular lymphoma (FL) of B cell type is a common mature B cell neoplasm of germinal center origin that effaces the nodal architecture usually by back to back follicles. These are usually composed of an admixed population of small centrocytes with cleaved and angulated nuclei and centroblasts whic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | Human Pathology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772736X22000287 |
| _version_ | 1811293223486750720 |
|---|---|
| author | Christian K. Hirt Christine R. Bryke Sarmad H. Jassim |
| author_facet | Christian K. Hirt Christine R. Bryke Sarmad H. Jassim |
| author_sort | Christian K. Hirt |
| collection | DOAJ |
| description | Follicular lymphoma (FL) of B cell type is a common mature B cell neoplasm of germinal center origin that effaces the nodal architecture usually by back to back follicles. These are usually composed of an admixed population of small centrocytes with cleaved and angulated nuclei and centroblasts which are larger cells with dispersed chromatin and variably prominent peripheral nucleoli. While the proliferation index using Ki-67 (MIB1) is not used to grade follicular lymphomas, studies have shown that FL with a higher proliferation index may behave differently and more aggressively than FL with lower proliferation index. In addition, it has been repeatedly recognized that additional chromosomal aberrations affect the biologic and clinical behavior of FL. In this manuscript, we report four different cases of FL diagnosed from small core needle biopsies and discuss the challenges faced interpreting limited biopsies, significance of incorporating the proliferation fraction, and additional chromosomal or gene aberrations from concurrent cytogenetic studies. |
| first_indexed | 2024-04-13T04:58:15Z |
| format | Article |
| id | doaj.art-a618ccb2c64648829a058a640d4f34ce |
| institution | Directory Open Access Journal |
| issn | 2772-736X |
| language | English |
| last_indexed | 2024-04-13T04:58:15Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology Reports |
| spelling | doaj.art-a618ccb2c64648829a058a640d4f34ce2022-12-22T03:01:25ZengElsevierHuman Pathology Reports2772-736X2022-06-0128300616Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogeneticsChristian K. Hirt0Christine R. Bryke1Sarmad H. Jassim2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston USABeth Israel Deaconess Medical Center, Harvard Medical School, Boston USACorresponding author.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston USAFollicular lymphoma (FL) of B cell type is a common mature B cell neoplasm of germinal center origin that effaces the nodal architecture usually by back to back follicles. These are usually composed of an admixed population of small centrocytes with cleaved and angulated nuclei and centroblasts which are larger cells with dispersed chromatin and variably prominent peripheral nucleoli. While the proliferation index using Ki-67 (MIB1) is not used to grade follicular lymphomas, studies have shown that FL with a higher proliferation index may behave differently and more aggressively than FL with lower proliferation index. In addition, it has been repeatedly recognized that additional chromosomal aberrations affect the biologic and clinical behavior of FL. In this manuscript, we report four different cases of FL diagnosed from small core needle biopsies and discuss the challenges faced interpreting limited biopsies, significance of incorporating the proliferation fraction, and additional chromosomal or gene aberrations from concurrent cytogenetic studies.http://www.sciencedirect.com/science/article/pii/S2772736X22000287Follicular lymphomaMUM1IRF4-DUSP22High proliferation index |
| spellingShingle | Christian K. Hirt Christine R. Bryke Sarmad H. Jassim Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics Human Pathology Reports Follicular lymphoma MUM1 IRF4-DUSP22 High proliferation index |
| title | Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| title_full | Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| title_fullStr | Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| title_full_unstemmed | Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| title_short | Challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| title_sort | challenging cases of follicular lymphoma diagnosed by core needle biopsy incorporating proliferation index and cytogenetics |
| topic | Follicular lymphoma MUM1 IRF4-DUSP22 High proliferation index |
| url | http://www.sciencedirect.com/science/article/pii/S2772736X22000287 |
| work_keys_str_mv | AT christiankhirt challengingcasesoffollicularlymphomadiagnosedbycoreneedlebiopsyincorporatingproliferationindexandcytogenetics AT christinerbryke challengingcasesoffollicularlymphomadiagnosedbycoreneedlebiopsyincorporatingproliferationindexandcytogenetics AT sarmadhjassim challengingcasesoffollicularlymphomadiagnosedbycoreneedlebiopsyincorporatingproliferationindexandcytogenetics |