Morphological and functional correlates of vestibular synaptic deafferentation and repair in a mouse model of acute-onset vertigo

Morphological and functional correlates of vestibular synaptic deafferentation and repair in a mouse model of acute-onset vertigo

Damage to cochlear primary afferent synapses has been shown to be a key factor in various auditory pathologies. Similarly, the selective lesioning of primary vestibular synapses might be an underlying cause of peripheral vestibulopathies that cause vertigo and dizziness, for which the pathophysiolog...

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Bibliographic Details
Main Authors: Raphaelle Cassel, Pierrick Bordiga, Julie Carcaud, François Simon, Mathieu Beraneck, Anne Le Gall, Anne Benoit, Valentine Bouet, Bruno Philoxene, Stéphane Besnard, Isabelle Watabe, David Pericat, Charlotte Hautefort, Axel Assie, Alain Tonetto, Jonas Dyhrfjeld-Johnsen, Jordi Llorens, Brahim Tighilet, Christian Chabbert
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Disease Models & Mechanisms
Subjects:
Vestibule
Synapses
Excitotoxicity
Plasticity
Vestibular disorders
Online Access:http://dmm.biologists.org/content/12/7/dmm039115

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