Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses
The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/8/1800 |
| _version_ | 1797570658737061888 |
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| author | Nakarin Suwannarach Jaturong Kumla Kanaporn Sujarit Thanawat Pattananandecha Chalermpong Saenjum Saisamorn Lumyong |
| author_facet | Nakarin Suwannarach Jaturong Kumla Kanaporn Sujarit Thanawat Pattananandecha Chalermpong Saenjum Saisamorn Lumyong |
| author_sort | Nakarin Suwannarach |
| collection | DOAJ |
| description | The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future. |
| first_indexed | 2024-03-10T20:28:23Z |
| format | Article |
| id | doaj.art-a6192a0b6de342969eefabfde1e25dd9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:28:23Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a6192a0b6de342969eefabfde1e25dd92023-11-19T21:37:11ZengMDPI AGMolecules1420-30492020-04-01258180010.3390/molecules25081800Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for CoronavirusesNakarin Suwannarach0Jaturong Kumla1Kanaporn Sujarit2Thanawat Pattananandecha3Chalermpong Saenjum4Saisamorn Lumyong5Research Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, ThailandThe inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.https://www.mdpi.com/1420-3049/25/8/1800antiviral agentsdrug discoverycoronavirusesfungal metabolitesimmunomodulatory agentsnatural products |
| spellingShingle | Nakarin Suwannarach Jaturong Kumla Kanaporn Sujarit Thanawat Pattananandecha Chalermpong Saenjum Saisamorn Lumyong Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses Molecules antiviral agents drug discovery coronaviruses fungal metabolites immunomodulatory agents natural products |
| title | Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses |
| title_full | Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses |
| title_fullStr | Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses |
| title_full_unstemmed | Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses |
| title_short | Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses |
| title_sort | natural bioactive compounds from fungi as potential candidates for protease inhibitors and immunomodulators to apply for coronaviruses |
| topic | antiviral agents drug discovery coronaviruses fungal metabolites immunomodulatory agents natural products |
| url | https://www.mdpi.com/1420-3049/25/8/1800 |
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