Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle
The immune-acquired responses after vaccination vary depending on the type of vaccine and the individual. The purpose of this study was to investigate the relationship between the acquisition of immunity and the side effects, health status, and lifestyle after completion of the second dose of AZD122...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/12/1473 |
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| author | Hyunji Choi Sun-Min Lee Seungjin Lim Kyung-Hwa Shin Taeyun Kim Won-joo Kim Misook Yun Seung-Hwan Oh |
| author_facet | Hyunji Choi Sun-Min Lee Seungjin Lim Kyung-Hwa Shin Taeyun Kim Won-joo Kim Misook Yun Seung-Hwan Oh |
| author_sort | Hyunji Choi |
| collection | DOAJ |
| description | The immune-acquired responses after vaccination vary depending on the type of vaccine and the individual. The purpose of this study was to investigate the relationship between the acquisition of immunity and the side effects, health status, and lifestyle after completion of the second dose of AZD1222. Blood samples were collected after a second dose of AZD1222. The Euroimmun Anti-SARS-CoV-2 ELISA (IgG) for anti-S1 antibody, the cPASS SARS-CoV-2 neutralizing antibody detection kit for the surrogate virus neutralization test, and the T-spot Discovery SARS-CoV-2 kit were used to identify cellular immunogenicity. Patient experience of adverse effects was investigated using questionnaires. Information on health status and lifestyle were collected from the most recent health checkup data. Generally, females experience more reactogenicity in both intensity and duration. The rash of the first shot and chills of the second shot were associated with humoral immunity. However, comprehensive adverse effects had no correlation with humoral and cellular immunity. The T-spot-positive group had a higher creatinine level, which reflects muscle mass, than the T-spot-negative group. Males presented a higher level of T-spot assays. Body mass index and age were negatively correlated with the T-spot assay and anti-S1 antibody, respectively. Immune acquisition after the second AZD1222 shot was not associated with reactogenicity. However, individuals’ sex, age, and BMI were found to be associated with immunogenicity after vaccination. |
| first_indexed | 2024-03-10T03:56:21Z |
| format | Article |
| id | doaj.art-a6195dc38c014becb4da4912eccfc6cb |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T03:56:21Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a6195dc38c014becb4da4912eccfc6cb2023-11-23T10:54:50ZengMDPI AGVaccines2076-393X2021-12-01912147310.3390/vaccines9121473Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and LifestyleHyunji Choi0Sun-Min Lee1Seungjin Lim2Kyung-Hwa Shin3Taeyun Kim4Won-joo Kim5Misook Yun6Seung-Hwan Oh7Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDivision of Infectious Diseases, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Laboratory Medicine, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, KoreaDepartment of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDivision of Biostatistics, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDepartment of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaThe immune-acquired responses after vaccination vary depending on the type of vaccine and the individual. The purpose of this study was to investigate the relationship between the acquisition of immunity and the side effects, health status, and lifestyle after completion of the second dose of AZD1222. Blood samples were collected after a second dose of AZD1222. The Euroimmun Anti-SARS-CoV-2 ELISA (IgG) for anti-S1 antibody, the cPASS SARS-CoV-2 neutralizing antibody detection kit for the surrogate virus neutralization test, and the T-spot Discovery SARS-CoV-2 kit were used to identify cellular immunogenicity. Patient experience of adverse effects was investigated using questionnaires. Information on health status and lifestyle were collected from the most recent health checkup data. Generally, females experience more reactogenicity in both intensity and duration. The rash of the first shot and chills of the second shot were associated with humoral immunity. However, comprehensive adverse effects had no correlation with humoral and cellular immunity. The T-spot-positive group had a higher creatinine level, which reflects muscle mass, than the T-spot-negative group. Males presented a higher level of T-spot assays. Body mass index and age were negatively correlated with the T-spot assay and anti-S1 antibody, respectively. Immune acquisition after the second AZD1222 shot was not associated with reactogenicity. However, individuals’ sex, age, and BMI were found to be associated with immunogenicity after vaccination.https://www.mdpi.com/2076-393X/9/12/1473SARS-CoV-2vaccinesadverse effectneutralizing antibodycellular immune responseBMI |
| spellingShingle | Hyunji Choi Sun-Min Lee Seungjin Lim Kyung-Hwa Shin Taeyun Kim Won-joo Kim Misook Yun Seung-Hwan Oh Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle Vaccines SARS-CoV-2 vaccines adverse effect neutralizing antibody cellular immune response BMI |
| title | Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle |
| title_full | Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle |
| title_fullStr | Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle |
| title_full_unstemmed | Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle |
| title_short | Immunogenicity after Second ChAdOx1 nCoV-19 (AZD1222) Vaccination According to the Individual Reactogenicity, Health Status and Lifestyle |
| title_sort | immunogenicity after second chadox1 ncov 19 azd1222 vaccination according to the individual reactogenicity health status and lifestyle |
| topic | SARS-CoV-2 vaccines adverse effect neutralizing antibody cellular immune response BMI |
| url | https://www.mdpi.com/2076-393X/9/12/1473 |
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