Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan
Background: Since 2015, 13-valent pneumococcal conjugate vaccine (PCV13) was included in the national immunization program in Taiwan. Subsequently, the serotypes of the main circulating Streptococcus pneumoniae strains have changed. PCV administration is also associated with changes in the antimicro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222001475 |
| _version_ | 1797869856902610944 |
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| author | Hsiang Huang Chien-Yu Lin Nan-Chang Chiu Daniel Tsung-Ning Huang Ching-Ying Huang Hsin Chi |
| author_facet | Hsiang Huang Chien-Yu Lin Nan-Chang Chiu Daniel Tsung-Ning Huang Ching-Ying Huang Hsin Chi |
| author_sort | Hsiang Huang |
| collection | DOAJ |
| description | Background: Since 2015, 13-valent pneumococcal conjugate vaccine (PCV13) was included in the national immunization program in Taiwan. Subsequently, the serotypes of the main circulating Streptococcus pneumoniae strains have changed. PCV administration is also associated with changes in the antimicrobial susceptibility of S. pneumoniae strains. Therefore, in this study, we analyzed the serotype distribution and antimicrobial susceptibility of S. pneumoniae in pediatric infections. Methods: Children with S. pneumoniae infections, including invasive pneumococcal disease (IPD) and non-IPD, were enrolled from January 2010 to December 2020. The samples were collected from Mackay Memorial Hospital, MacKay Children's Hospital, and Hsinchu Mackay Hospital in Taiwan. We analyzed the epidemiology of sample collection site, infection diagnosis, and the serotype and antimicrobial susceptibility of S. pneumoniae strains. The study period was divided into time points before and after PCV13 administration. Results: In total, 322 isolates were collected during the study period. The incidence of IPD declined annually, from 29.7% before 2015 to 7.3% after 2015 (p < 0.001). The prevalence of serotype 19 A had increased gradually since 2010 but declined rapidly after 2013. Serotypes 15 A and 23 A were the most common serotypes after 2015. The non-susceptibility of the S. pneumoniae isolates to penicillin, cefotaxime, and ceftriaxone decreased. Based on meningitis breakpoints, the non-susceptibility to cefotaxime and ceftriaxone gradually decreased, but increased in 2020. Conclusion: PCV13 was considerably effective in reducing the incidence of IPD in children; however, the prevalence of serotypes 15 A and 23 A increased. The increase in antimicrobial non-susceptibility caused by non-vaccine serotypes must be continuously monitored. |
| first_indexed | 2024-04-10T00:18:06Z |
| format | Article |
| id | doaj.art-a61b05f6cbee4386a049db4db85df0fa |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-10T00:18:06Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-a61b05f6cbee4386a049db4db85df0fa2023-03-16T05:03:26ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822023-04-01562299310Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in TaiwanHsiang Huang0Chien-Yu Lin1Nan-Chang Chiu2Daniel Tsung-Ning Huang3Ching-Ying Huang4Hsin Chi5Department of Pediatrics, MacKay Children's Hospital, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei, Taiwan; Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, Taiwan; Corresponding author. No.92, Sec. 2, Zhongshan North Rd., Zhongshan Dist., Taipei City, 104217, Taiwan.Background: Since 2015, 13-valent pneumococcal conjugate vaccine (PCV13) was included in the national immunization program in Taiwan. Subsequently, the serotypes of the main circulating Streptococcus pneumoniae strains have changed. PCV administration is also associated with changes in the antimicrobial susceptibility of S. pneumoniae strains. Therefore, in this study, we analyzed the serotype distribution and antimicrobial susceptibility of S. pneumoniae in pediatric infections. Methods: Children with S. pneumoniae infections, including invasive pneumococcal disease (IPD) and non-IPD, were enrolled from January 2010 to December 2020. The samples were collected from Mackay Memorial Hospital, MacKay Children's Hospital, and Hsinchu Mackay Hospital in Taiwan. We analyzed the epidemiology of sample collection site, infection diagnosis, and the serotype and antimicrobial susceptibility of S. pneumoniae strains. The study period was divided into time points before and after PCV13 administration. Results: In total, 322 isolates were collected during the study period. The incidence of IPD declined annually, from 29.7% before 2015 to 7.3% after 2015 (p < 0.001). The prevalence of serotype 19 A had increased gradually since 2010 but declined rapidly after 2013. Serotypes 15 A and 23 A were the most common serotypes after 2015. The non-susceptibility of the S. pneumoniae isolates to penicillin, cefotaxime, and ceftriaxone decreased. Based on meningitis breakpoints, the non-susceptibility to cefotaxime and ceftriaxone gradually decreased, but increased in 2020. Conclusion: PCV13 was considerably effective in reducing the incidence of IPD in children; however, the prevalence of serotypes 15 A and 23 A increased. The increase in antimicrobial non-susceptibility caused by non-vaccine serotypes must be continuously monitored.http://www.sciencedirect.com/science/article/pii/S1684118222001475Antimicrobial susceptibilityPediatric infectionsPneumococcal conjugate vaccineSerotype prevalenceStreptococcus pneumoniae |
| spellingShingle | Hsiang Huang Chien-Yu Lin Nan-Chang Chiu Daniel Tsung-Ning Huang Ching-Ying Huang Hsin Chi Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan Journal of Microbiology, Immunology and Infection Antimicrobial susceptibility Pediatric infections Pneumococcal conjugate vaccine Serotype prevalence Streptococcus pneumoniae |
| title | Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan |
| title_full | Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan |
| title_fullStr | Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan |
| title_full_unstemmed | Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan |
| title_short | Antimicrobial susceptibility and serotype replacement of Streptococcus pneumoniae in children before and after PCV13 introduction in Taiwan |
| title_sort | antimicrobial susceptibility and serotype replacement of streptococcus pneumoniae in children before and after pcv13 introduction in taiwan |
| topic | Antimicrobial susceptibility Pediatric infections Pneumococcal conjugate vaccine Serotype prevalence Streptococcus pneumoniae |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222001475 |
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