Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head
AbstractThis study is focussed on evaluating and comparing two mediators of osteoclast, osteoprotegerin (OPG) and nuclear factor-κB ligand (RANKL), in plasma and tissue levels in patients with steroid-induced osteonecrosis of femoral head (SIONFH). Subjects were included in this cross-sectional case...
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| Format: | Article |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2020.1774596 |
| _version_ | 1797788825287655424 |
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| author | Min-Cong He Jin Zhang Xiao-Jun Chen Ying-Shan Shen Bin Fang Yi-Xian Qin Wei He Qiu-Shi Wei |
| author_facet | Min-Cong He Jin Zhang Xiao-Jun Chen Ying-Shan Shen Bin Fang Yi-Xian Qin Wei He Qiu-Shi Wei |
| author_sort | Min-Cong He |
| collection | DOAJ |
| description | AbstractThis study is focussed on evaluating and comparing two mediators of osteoclast, osteoprotegerin (OPG) and nuclear factor-κB ligand (RANKL), in plasma and tissue levels in patients with steroid-induced osteonecrosis of femoral head (SIONFH). Subjects were included in this cross-sectional case-control study in 2016. Bone histomorphology, immunohistochemistry, Western blotting, OPG and RANKL plasma levels, post-hoc statistical power and receiver-operating characteristic (ROC) curves were evaluated. Eighty-six patients diagnosed with SIONFH and 51 healthy subjects were included. OPG expression levels in bone samples increased with ARCO stage, and RANKL expression levels decreased with ARCO stages. Plasma OPG and RANKL levels were significantly higher in the SIONFH group compared with the healthy control group. The plasma OPG level and ratio of OPG and RANKL were positively associated with ARCO stages and significantly higher in stages III and IV. Plasma RANKL levels were negatively associated with ARCO stage and were significantly higher in ARCO stages II and III. Plasma OPG and RANKL may represent potential biomarkers during SIONFH at different stages. Higher plasma OPG levels indicated late-stage SIONFH, and higher plasma RANKL levels indicated early stage. Our findings may provide a clue for the development of diagnostic tools and therapies for SIONFH. |
| first_indexed | 2024-03-13T01:40:58Z |
| format | Article |
| id | doaj.art-a61b5732f962418a810533998a95f800 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-13T01:40:58Z |
| publishDate | 2020-01-01 |
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| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-a61b5732f962418a810533998a95f8002023-07-03T14:04:56ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-014811036104610.1080/21691401.2020.1774596Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral headMin-Cong He0Jin Zhang1Xiao-Jun Chen2Ying-Shan Shen3Bin Fang4Yi-Xian Qin5Wei He6Qiu-Shi Wei7The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaDepartment of Anatomy, Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaFirst Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USAThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR ChinaAbstractThis study is focussed on evaluating and comparing two mediators of osteoclast, osteoprotegerin (OPG) and nuclear factor-κB ligand (RANKL), in plasma and tissue levels in patients with steroid-induced osteonecrosis of femoral head (SIONFH). Subjects were included in this cross-sectional case-control study in 2016. Bone histomorphology, immunohistochemistry, Western blotting, OPG and RANKL plasma levels, post-hoc statistical power and receiver-operating characteristic (ROC) curves were evaluated. Eighty-six patients diagnosed with SIONFH and 51 healthy subjects were included. OPG expression levels in bone samples increased with ARCO stage, and RANKL expression levels decreased with ARCO stages. Plasma OPG and RANKL levels were significantly higher in the SIONFH group compared with the healthy control group. The plasma OPG level and ratio of OPG and RANKL were positively associated with ARCO stages and significantly higher in stages III and IV. Plasma RANKL levels were negatively associated with ARCO stage and were significantly higher in ARCO stages II and III. Plasma OPG and RANKL may represent potential biomarkers during SIONFH at different stages. Higher plasma OPG levels indicated late-stage SIONFH, and higher plasma RANKL levels indicated early stage. Our findings may provide a clue for the development of diagnostic tools and therapies for SIONFH.https://www.tandfonline.com/doi/10.1080/21691401.2020.1774596Osteoclastic activitysteriod-induced osteonecrosis of femoral headosteoprotegerinnuclear factor-κB ligand |
| spellingShingle | Min-Cong He Jin Zhang Xiao-Jun Chen Ying-Shan Shen Bin Fang Yi-Xian Qin Wei He Qiu-Shi Wei Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head Artificial Cells, Nanomedicine, and Biotechnology Osteoclastic activity steriod-induced osteonecrosis of femoral head osteoprotegerin nuclear factor-κB ligand |
| title | Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head |
| title_full | Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head |
| title_fullStr | Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head |
| title_full_unstemmed | Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head |
| title_short | Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head |
| title_sort | osteoclastic activity was associated with the development of steroid induced osteonecrosis of femoral head |
| topic | Osteoclastic activity steriod-induced osteonecrosis of femoral head osteoprotegerin nuclear factor-κB ligand |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2020.1774596 |
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