Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis
Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undiff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/11/3264 |
| _version_ | 1797548829404299264 |
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| author | Hossein Tabatabaeian Samantha Peiling Yang Yvonne Tay |
| author_facet | Hossein Tabatabaeian Samantha Peiling Yang Yvonne Tay |
| author_sort | Hossein Tabatabaeian |
| collection | DOAJ |
| description | Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer. |
| first_indexed | 2024-03-10T15:05:19Z |
| format | Article |
| id | doaj.art-a61bc41b8031439c99597152105d02a5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:05:19Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a61bc41b8031439c99597152105d02a52023-11-20T19:49:18ZengMDPI AGCancers2072-66942020-11-011211326410.3390/cancers12113264Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer PathogenesisHossein Tabatabaeian0Samantha Peiling Yang1Yvonne Tay2Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeEndocrinology Division, Department of Medicine, National University Hospital, Singapore 119228, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeThyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.https://www.mdpi.com/2072-6694/12/11/3264thyroid carcinomanon-coding RNAradioactive iodinedrug resistanceprognosis |
| spellingShingle | Hossein Tabatabaeian Samantha Peiling Yang Yvonne Tay Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis Cancers thyroid carcinoma non-coding RNA radioactive iodine drug resistance prognosis |
| title | Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis |
| title_full | Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis |
| title_fullStr | Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis |
| title_full_unstemmed | Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis |
| title_short | Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis |
| title_sort | non coding rnas uncharted mediators of thyroid cancer pathogenesis |
| topic | thyroid carcinoma non-coding RNA radioactive iodine drug resistance prognosis |
| url | https://www.mdpi.com/2072-6694/12/11/3264 |
| work_keys_str_mv | AT hosseintabatabaeian noncodingrnasunchartedmediatorsofthyroidcancerpathogenesis AT samanthapeilingyang noncodingrnasunchartedmediatorsofthyroidcancerpathogenesis AT yvonnetay noncodingrnasunchartedmediatorsofthyroidcancerpathogenesis |