A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
Abstract Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis facto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02930-z |
| _version_ | 1811334643713048576 |
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| author | Sijia Wang Liang Li Christopher Cook Yufei Zhang Yumin Xia Yale Liu |
| author_facet | Sijia Wang Liang Li Christopher Cook Yufei Zhang Yumin Xia Yale Liu |
| author_sort | Sijia Wang |
| collection | DOAJ |
| description | Abstract Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) acts on miscellaneous cells via binding to fibroblast growth factor-inducible 14 (Fn14) and exerts pleiotropic functions in the regulation of divergent stem cell fates. TWEAK/Fn14 signaling can regulate the proliferation, differentiation, and migration of multiple SPCs as well as tumorigenesis in certain contexts. Although TWEAK’s roles in modulating multiple SPCs are sparsely reported, the systemic effector functions of this multifaceted protein have not been fully elucidated. In this review, we summarized the fate decisions of TWEAK/Fn14 signaling on multiple stem cells and characterized its potential in stem cell therapy. |
| first_indexed | 2024-04-13T17:12:06Z |
| format | Article |
| id | doaj.art-a61be2f16cc54e828db74f6028144b97 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-13T17:12:06Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-a61be2f16cc54e828db74f6028144b972022-12-22T02:38:15ZengBMCStem Cell Research & Therapy1757-65122022-06-0113111010.1186/s13287-022-02930-zA potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic reviewSijia Wang0Liang Li1Christopher Cook2Yufei Zhang3Yumin Xia4Yale Liu5Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Thoracic Surgery, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, BerkeleyDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) acts on miscellaneous cells via binding to fibroblast growth factor-inducible 14 (Fn14) and exerts pleiotropic functions in the regulation of divergent stem cell fates. TWEAK/Fn14 signaling can regulate the proliferation, differentiation, and migration of multiple SPCs as well as tumorigenesis in certain contexts. Although TWEAK’s roles in modulating multiple SPCs are sparsely reported, the systemic effector functions of this multifaceted protein have not been fully elucidated. In this review, we summarized the fate decisions of TWEAK/Fn14 signaling on multiple stem cells and characterized its potential in stem cell therapy.https://doi.org/10.1186/s13287-022-02930-zTWEAK/Fn14Stem and progenitor cellsFate decision |
| spellingShingle | Sijia Wang Liang Li Christopher Cook Yufei Zhang Yumin Xia Yale Liu A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review Stem Cell Research & Therapy TWEAK/Fn14 Stem and progenitor cells Fate decision |
| title | A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review |
| title_full | A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review |
| title_fullStr | A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review |
| title_full_unstemmed | A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review |
| title_short | A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review |
| title_sort | potential fate decision landscape of the tweak fn14 axis on stem and progenitor cells a systematic review |
| topic | TWEAK/Fn14 Stem and progenitor cells Fate decision |
| url | https://doi.org/10.1186/s13287-022-02930-z |
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