Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease
Cardiorespiratory fitness (CRF) is an excellent marker of overall health. This study aimed to assess criterion validity and responsiveness of estimated CRF models (eCRF) in patients with inflammatory joint disease (IJD). CRF was measured directly as peak oxygen uptake (VO<sub>2peak</sub>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/21/6753 |
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| author | Kristine Røren Nordén Hanne Dagfinrud Anne Grete Semb Jonny Hisdal George S. Metsios Joseph Sexton Camilla Fongen Emilie Andrea Bakke Anne Therese Tveter |
| author_facet | Kristine Røren Nordén Hanne Dagfinrud Anne Grete Semb Jonny Hisdal George S. Metsios Joseph Sexton Camilla Fongen Emilie Andrea Bakke Anne Therese Tveter |
| author_sort | Kristine Røren Nordén |
| collection | DOAJ |
| description | Cardiorespiratory fitness (CRF) is an excellent marker of overall health. This study aimed to assess criterion validity and responsiveness of estimated CRF models (eCRF) in patients with inflammatory joint disease (IJD). CRF was measured directly as peak oxygen uptake (VO<sub>2peak</sub>) by a Cardiopulmonary Exercise Test (CPET), while one generic eCRF model (eCRF<sub>GEN</sub>) and two disease-specific eCRF models (eCRF<sub>ALT</sub> and eCRF<sub>PGA</sub>) were used to estimate CRF at baseline and after 3 months in 55 Norwegian patients with IJD. Moderate correlations were observed between eCRF<sub>GEN</sub>, eCRF<sub>ALT</sub>, eCRF<sub>PGA</sub>, and VO<sub>2peak</sub> at baseline (ICC 0.60, 0.64 and 0.62, respectively) and 3 months (ICC 0.62, 0.65 and 0.57, respectively). All eCRF models overestimated measured VO<sub>2peak</sub>, and there was large variability in agreement of individual measurements at baseline and at 3 months. Weak correlations were observed for responsiveness of eCRF<sub>GEN</sub> (ICC 0.39), eCRF<sub>ALT</sub> (ICC 0.40) and eCRF<sub>PGA</sub> (ICC 0.39). Mean differences between change in eCRF models and change in VO<sub>2peak</sub> were small, but the wide limits of agreement exceeded the pre-defined clinically acceptable margins. The eCRF models possessed adequate ability to detect ≥3.5 mL/kg/min improvement in VO<sub>2peak</sub>. eCRF may suffice for group-level assessment, but caution is advised when applying eCRF to individual patients with IJD. |
| first_indexed | 2024-03-11T11:27:36Z |
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| id | doaj.art-a61e07b4b18b46c59d3244475b9ca80f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T11:27:36Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a61e07b4b18b46c59d3244475b9ca80f2023-11-10T15:06:19ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011221675310.3390/jcm12216753Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint DiseaseKristine Røren Nordén0Hanne Dagfinrud1Anne Grete Semb2Jonny Hisdal3George S. Metsios4Joseph Sexton5Camilla Fongen6Emilie Andrea Bakke7Anne Therese Tveter8Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, 0319 Oslo, NorwayCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, 0319 Oslo, NorwayPreventive Cardio-Rheuma Clinic, Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Division of Rheumatology and Research, Diakonhjemmet Hospital, 0319 Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, NorwayDepartment of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, GreeceCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Division of Rheumatology and Research, Diakonhjemmet Hospital, 0319 Oslo, NorwayCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, 0319 Oslo, NorwayCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, 0319 Oslo, NorwayCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, 0319 Oslo, NorwayCardiorespiratory fitness (CRF) is an excellent marker of overall health. This study aimed to assess criterion validity and responsiveness of estimated CRF models (eCRF) in patients with inflammatory joint disease (IJD). CRF was measured directly as peak oxygen uptake (VO<sub>2peak</sub>) by a Cardiopulmonary Exercise Test (CPET), while one generic eCRF model (eCRF<sub>GEN</sub>) and two disease-specific eCRF models (eCRF<sub>ALT</sub> and eCRF<sub>PGA</sub>) were used to estimate CRF at baseline and after 3 months in 55 Norwegian patients with IJD. Moderate correlations were observed between eCRF<sub>GEN</sub>, eCRF<sub>ALT</sub>, eCRF<sub>PGA</sub>, and VO<sub>2peak</sub> at baseline (ICC 0.60, 0.64 and 0.62, respectively) and 3 months (ICC 0.62, 0.65 and 0.57, respectively). All eCRF models overestimated measured VO<sub>2peak</sub>, and there was large variability in agreement of individual measurements at baseline and at 3 months. Weak correlations were observed for responsiveness of eCRF<sub>GEN</sub> (ICC 0.39), eCRF<sub>ALT</sub> (ICC 0.40) and eCRF<sub>PGA</sub> (ICC 0.39). Mean differences between change in eCRF models and change in VO<sub>2peak</sub> were small, but the wide limits of agreement exceeded the pre-defined clinically acceptable margins. The eCRF models possessed adequate ability to detect ≥3.5 mL/kg/min improvement in VO<sub>2peak</sub>. eCRF may suffice for group-level assessment, but caution is advised when applying eCRF to individual patients with IJD.https://www.mdpi.com/2077-0383/12/21/6753cardiorespiratory fitnessinflammatory joint diseaserheumatoid arthritisspondyloarthritisvalidityresponsiveness |
| spellingShingle | Kristine Røren Nordén Hanne Dagfinrud Anne Grete Semb Jonny Hisdal George S. Metsios Joseph Sexton Camilla Fongen Emilie Andrea Bakke Anne Therese Tveter Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease Journal of Clinical Medicine cardiorespiratory fitness inflammatory joint disease rheumatoid arthritis spondyloarthritis validity responsiveness |
| title | Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease |
| title_full | Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease |
| title_fullStr | Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease |
| title_full_unstemmed | Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease |
| title_short | Criterion Validity and Responsiveness of Estimated Cardiorespiratory Fitness Models in Patients with Inflammatory Joint Disease |
| title_sort | criterion validity and responsiveness of estimated cardiorespiratory fitness models in patients with inflammatory joint disease |
| topic | cardiorespiratory fitness inflammatory joint disease rheumatoid arthritis spondyloarthritis validity responsiveness |
| url | https://www.mdpi.com/2077-0383/12/21/6753 |
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