Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis
BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and Tregs in peripheral blood of patients with AD.Meth...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.777992/full |
| _version_ | 1811328479467143168 |
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| author | Dao-jun Zhang Fei Hao Tian Qian Hai-xing Cheng |
| author_facet | Dao-jun Zhang Fei Hao Tian Qian Hai-xing Cheng |
| author_sort | Dao-jun Zhang |
| collection | DOAJ |
| description | BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and Tregs in peripheral blood of patients with AD.MethodsA comprehensive literature search was performed in PubMed, Embase, China National Knowledge Internet, and Wan-fang Data from the day of inception of this study to July 2021. Two authors independently extracted the data, which were pooled and calculated using Stata software version 15.ResultsA total of eight studies met the inclusion criteria. Compared with control group, patients with AD had an increased proportion of Th22 cells [weighted mean difference (WMD) = 2.07, 95% CI (1.33, 2.81), p < 0.001], Th17 cells [WMD = 1.04, 95% CI [0.66, 1.43], p < 0.001], IL-17 [WMD = 17.56, 95% CI (11.1, 24.03), p < 0.001], and a decreased proportion of Tregs [WMD = −2.49, 95% CI (−2.93, −2.05), p < 0.001] in peripheral blood. The subgroup analysis showed that patients with higher disease severity had higher levels of Th22 [mild: WMD = 1.33, 95% CI (1.24, 1.41), p < 0.001; moderate: WMD = 1.41, 95% CI (1.36, 1.54), p < 0.001; severe: WMD = 3.46, 95% CI (3.34, 2.81), p < 0.001] and lower levels of Tregs [mild: WMD = −1.43, 95% CI (−1.75, −1.11), p < 0.001; moderate: WMD = −2.16, 95% CI (−2.46, −1.86), p < 0.001; severe: WMD = −2.96, 95% CI (−3.25, −2.67), p < 0.001] in peripheral blood compared to healthy controls.ConclusionThe random effect model of the meta-analysis showed patients with AD had an increased proportion of Th22 cells, Th17 cells, and IL-17, whereas a decreased proportion of Tregs was found in peripheral blood. The results demonstrated that Th22 cells, Th17 cells, IL-17, and Tregs may be involved in the pathogenic mechanisms of AD. |
| first_indexed | 2024-04-13T15:25:49Z |
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| id | doaj.art-a622f039bb83495b8d50b53d9b197a4a |
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| language | English |
| last_indexed | 2024-04-13T15:25:49Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-a622f039bb83495b8d50b53d9b197a4a2022-12-22T02:41:30ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-04-011010.3389/fped.2022.777992777992Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-AnalysisDao-jun ZhangFei HaoTian QianHai-xing ChengBackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and Tregs in peripheral blood of patients with AD.MethodsA comprehensive literature search was performed in PubMed, Embase, China National Knowledge Internet, and Wan-fang Data from the day of inception of this study to July 2021. Two authors independently extracted the data, which were pooled and calculated using Stata software version 15.ResultsA total of eight studies met the inclusion criteria. Compared with control group, patients with AD had an increased proportion of Th22 cells [weighted mean difference (WMD) = 2.07, 95% CI (1.33, 2.81), p < 0.001], Th17 cells [WMD = 1.04, 95% CI [0.66, 1.43], p < 0.001], IL-17 [WMD = 17.56, 95% CI (11.1, 24.03), p < 0.001], and a decreased proportion of Tregs [WMD = −2.49, 95% CI (−2.93, −2.05), p < 0.001] in peripheral blood. The subgroup analysis showed that patients with higher disease severity had higher levels of Th22 [mild: WMD = 1.33, 95% CI (1.24, 1.41), p < 0.001; moderate: WMD = 1.41, 95% CI (1.36, 1.54), p < 0.001; severe: WMD = 3.46, 95% CI (3.34, 2.81), p < 0.001] and lower levels of Tregs [mild: WMD = −1.43, 95% CI (−1.75, −1.11), p < 0.001; moderate: WMD = −2.16, 95% CI (−2.46, −1.86), p < 0.001; severe: WMD = −2.96, 95% CI (−3.25, −2.67), p < 0.001] in peripheral blood compared to healthy controls.ConclusionThe random effect model of the meta-analysis showed patients with AD had an increased proportion of Th22 cells, Th17 cells, and IL-17, whereas a decreased proportion of Tregs was found in peripheral blood. The results demonstrated that Th22 cells, Th17 cells, IL-17, and Tregs may be involved in the pathogenic mechanisms of AD.https://www.frontiersin.org/articles/10.3389/fped.2022.777992/fullTh22 cellsTh17 cellsIL-17tregsatopic dermatitis |
| spellingShingle | Dao-jun Zhang Fei Hao Tian Qian Hai-xing Cheng Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis Frontiers in Pediatrics Th22 cells Th17 cells IL-17 tregs atopic dermatitis |
| title | Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis |
| title_full | Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis |
| title_fullStr | Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis |
| title_full_unstemmed | Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis |
| title_short | Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis |
| title_sort | expression of helper and regulatory t cells in atopic dermatitis a meta analysis |
| topic | Th22 cells Th17 cells IL-17 tregs atopic dermatitis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.777992/full |
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