Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals
Background and Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy. Methods: In this multicenter cohort study, we enrolled patients with chronic h...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-06-01
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| Series: | Liver Cancer |
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| Online Access: | https://www.karger.com/Article/FullText/513705 |
| _version_ | 1819242361267421184 |
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| author | Tatsuya Minami Ryosuke Tateishi Naoto Fujiwara Ryo Nakagomi Takuma Nakatsuka Masaya Sato Koji Uchino Kenichiro Enooku Hayato Nakagawa Hidetaka Fujinaga Masashi Izumiya Kazuyuki Hanajiri Yoshinari Asaoka Yuji Kondo Yasuo Tanaka Motoyuki Otsuka Takamasa Ohki Masahiro Arai Atsushi Tanaka Kiyomi Yasuda Hideaki Miura Itsuro Ogata Toshiro Kamoshida Kazuaki Inoue Yukihiro Koike Masatoshi Akamatsu Hiroshi Mitsui Hajime Fujie Keiji Ogura Hideo Yoshida Tomonori Wada Kiyohiko Kurai Hisato Maekawa Shuntaro Obi Takuma Teratani Naohiko Masaki Kayo Nagashima Takashi Ishikawa Naoya Kato Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike |
| author_facet | Tatsuya Minami Ryosuke Tateishi Naoto Fujiwara Ryo Nakagomi Takuma Nakatsuka Masaya Sato Koji Uchino Kenichiro Enooku Hayato Nakagawa Hidetaka Fujinaga Masashi Izumiya Kazuyuki Hanajiri Yoshinari Asaoka Yuji Kondo Yasuo Tanaka Motoyuki Otsuka Takamasa Ohki Masahiro Arai Atsushi Tanaka Kiyomi Yasuda Hideaki Miura Itsuro Ogata Toshiro Kamoshida Kazuaki Inoue Yukihiro Koike Masatoshi Akamatsu Hiroshi Mitsui Hajime Fujie Keiji Ogura Hideo Yoshida Tomonori Wada Kiyohiko Kurai Hisato Maekawa Shuntaro Obi Takuma Teratani Naohiko Masaki Kayo Nagashima Takashi Ishikawa Naoya Kato Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike |
| author_sort | Tatsuya Minami |
| collection | DOAJ |
| description | Background and Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy. Methods: In this multicenter cohort study, we enrolled patients with chronic hepatitis C who achieved SVR with interferon (IFN)-based therapy (IFN group) or direct-acting antiviral (DAA) therapy (DAA group) between January 1, 1990, and December 31, 2018. The patients underwent regular surveillance for HCC. Cumulative incidence of and the risk factors for HCC development after SVR were assessed using the Kaplan-Meier method and Cox proportional hazard regression analysis, respectively. Results: Among 2,055 patients (840 in the IFN group and 1,215 in the DAA group), 75 developed HCC (41 in the IFN group and 34 in the DAA group) during the mean observation period of 4.1 years. The incidence rates of HCC at 1, 2, and 3 years were 1.2, 1.9, and 3.0%, respectively. Multivariate analysis revealed that in addition to older age, lower albumin level, lower platelet count, higher alpha-fetoprotein level, and absence of dyslipidemia, obesity (body mass index ≥25 kg/m2) and heavy alcohol consumption (≥60 g/day) were independent risk factors for HCC development, with adjusted hazard ratio (HR) of 2.53 (95% confidence interval [CI]: 1.51–4.25) and 2.56 (95% CI: 1.14–5.75), respectively. The adjusted HR was not significant between the 2 groups (DAA vs. IFN; HR 1.19, 95% CI: 0.61–2.33). Conclusions: Obesity and heavy alcohol consumption increased the risk of HCC development after SVR. |
| first_indexed | 2024-12-23T14:38:35Z |
| format | Article |
| id | doaj.art-a624671861264ea39d61aa7dc2a09d39 |
| institution | Directory Open Access Journal |
| issn | 2235-1795 1664-5553 |
| language | English |
| last_indexed | 2024-12-23T14:38:35Z |
| publishDate | 2021-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Liver Cancer |
| spelling | doaj.art-a624671861264ea39d61aa7dc2a09d392022-12-21T17:43:17ZengKarger PublishersLiver Cancer2235-17951664-55532021-06-0111110.1159/000513705513705Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with AntiviralsTatsuya Minami0Ryosuke Tateishi1Naoto Fujiwara2Ryo Nakagomi3Takuma Nakatsuka4Masaya Sato5Koji Uchino6Kenichiro Enooku7Hayato Nakagawa8Hidetaka Fujinaga9Masashi Izumiya10Kazuyuki Hanajiri11Yoshinari Asaoka12Yuji Kondo13Yasuo Tanaka14Motoyuki Otsuka15Takamasa Ohki16Masahiro Arai17Atsushi Tanaka18Kiyomi Yasuda19Hideaki Miura20Itsuro Ogata21Toshiro Kamoshida22Kazuaki Inoue23Yukihiro Koike24Masatoshi Akamatsu25Hiroshi Mitsui26Hajime Fujie27Keiji Ogura28Hideo Yoshida29Tomonori Wada30Kiyohiko Kurai31Hisato Maekawa32Shuntaro Obi33Takuma Teratani34https://orcid.org/0000-0001-5270-0752Naohiko Masaki35Kayo Nagashima36Takashi Ishikawa37Naoya Kato38Kyoji Moriya39Hiroshi Yotsuyanagi40Kazuhiko Koike41Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Mitsui Memorial Hospital, Tokyo, JapanDepartment of Gastroenterology, Toshiba General Hospital, Toshiba, JapanDepartment of Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Kiyokawa Hospital, Tokyo, JapanDepartment of Gastroenterology, Tokyo Yamate Medical Center, Tokyo, JapanDepartment of Gastroenterology, Kawakita General Hospital, Tokyo, JapanDepartment of Gastroenterology, Hitachi General Hospital, Hitachi, JapanDepartment of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, JapanDepartment of Gastroenterology, Kanto Central Hospital of the Mutual Aid Association of Public School Teacher, Tokyo, JapanDepartment of Gastroenterology, JR Tokyo General Hospital, Tokyo, JapanDepartment of Gastroenterology, Tokyo Teishin Hospital, Tokyo, JapanDepartment of Gastroenterology, Tokyo Shinjuku Medical Center, Tokyo, JapanDepartment of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, JapanDepartment of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, JapanDepartment of Gastroenterology, Sanraku Hospital, Tokyo, JapanKurai Kiyohiko Medical Clinic, Utsunomiya, JapanDepartment of Gastroenterology and Hepatology, Tokyo Takanawa Hospital, Tokyo, JapanDepartment of Gastroenterology and Hepatology, Kyoundo Hospital, Tokyo, JapanDepartment of Hepato-Biliary-Pancreatic medicine, NTT Medical Center Tokyo, Tokyo, JapanClinical Laboratory Department, Center Hospital of the National Center for Global Health and Medicine, Tokyo, JapanDepartment of Gastroenterology, National Disaster Medical Center, Tachikawa, JapanMarunouchi Clinic, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDivision of Infectious Disease and Applied Immunology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanBackground and Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy. Methods: In this multicenter cohort study, we enrolled patients with chronic hepatitis C who achieved SVR with interferon (IFN)-based therapy (IFN group) or direct-acting antiviral (DAA) therapy (DAA group) between January 1, 1990, and December 31, 2018. The patients underwent regular surveillance for HCC. Cumulative incidence of and the risk factors for HCC development after SVR were assessed using the Kaplan-Meier method and Cox proportional hazard regression analysis, respectively. Results: Among 2,055 patients (840 in the IFN group and 1,215 in the DAA group), 75 developed HCC (41 in the IFN group and 34 in the DAA group) during the mean observation period of 4.1 years. The incidence rates of HCC at 1, 2, and 3 years were 1.2, 1.9, and 3.0%, respectively. Multivariate analysis revealed that in addition to older age, lower albumin level, lower platelet count, higher alpha-fetoprotein level, and absence of dyslipidemia, obesity (body mass index ≥25 kg/m2) and heavy alcohol consumption (≥60 g/day) were independent risk factors for HCC development, with adjusted hazard ratio (HR) of 2.53 (95% confidence interval [CI]: 1.51–4.25) and 2.56 (95% CI: 1.14–5.75), respectively. The adjusted HR was not significant between the 2 groups (DAA vs. IFN; HR 1.19, 95% CI: 0.61–2.33). Conclusions: Obesity and heavy alcohol consumption increased the risk of HCC development after SVR.https://www.karger.com/Article/FullText/513705hepatitis cdirect-acting antiviralshepatocellular carcinomaobesity |
| spellingShingle | Tatsuya Minami Ryosuke Tateishi Naoto Fujiwara Ryo Nakagomi Takuma Nakatsuka Masaya Sato Koji Uchino Kenichiro Enooku Hayato Nakagawa Hidetaka Fujinaga Masashi Izumiya Kazuyuki Hanajiri Yoshinari Asaoka Yuji Kondo Yasuo Tanaka Motoyuki Otsuka Takamasa Ohki Masahiro Arai Atsushi Tanaka Kiyomi Yasuda Hideaki Miura Itsuro Ogata Toshiro Kamoshida Kazuaki Inoue Yukihiro Koike Masatoshi Akamatsu Hiroshi Mitsui Hajime Fujie Keiji Ogura Hideo Yoshida Tomonori Wada Kiyohiko Kurai Hisato Maekawa Shuntaro Obi Takuma Teratani Naohiko Masaki Kayo Nagashima Takashi Ishikawa Naoya Kato Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals Liver Cancer hepatitis c direct-acting antivirals hepatocellular carcinoma obesity |
| title | Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals |
| title_full | Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals |
| title_fullStr | Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals |
| title_full_unstemmed | Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals |
| title_short | Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals |
| title_sort | impact of obesity and heavy alcohol consumption on hepatocellular carcinoma development after hcv eradication with antivirals |
| topic | hepatitis c direct-acting antivirals hepatocellular carcinoma obesity |
| url | https://www.karger.com/Article/FullText/513705 |
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