Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-01-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325958219899534 |
| _version_ | 1811322744917196800 |
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| author | Suzy Maria MD Evy Yunihastuti MD, PhD Siti Rizny F. Saldi MSc Zubairi Djoerban MD |
| author_facet | Suzy Maria MD Evy Yunihastuti MD, PhD Siti Rizny F. Saldi MSc Zubairi Djoerban MD |
| author_sort | Suzy Maria MD |
| collection | DOAJ |
| description | There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm 3 at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success. |
| first_indexed | 2024-04-13T13:40:21Z |
| format | Article |
| id | doaj.art-a6247b4a483b4e689f7b9a81043537de |
| institution | Directory Open Access Journal |
| issn | 2325-9582 |
| language | English |
| last_indexed | 2024-04-13T13:40:21Z |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-a6247b4a483b4e689f7b9a81043537de2022-12-22T02:44:39ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95822020-01-011910.1177/2325958219899534Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned InterruptionSuzy Maria MD0Evy Yunihastuti MD, PhD1Siti Rizny F. Saldi MSc2Zubairi Djoerban MD3 HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia Center for Clinical Epidemiology and Evidence Based Medicine (CEEBM), Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia HIV Integrated Service, Dr. Cipto Mangunkusumo General Hospital, Jakarta, IndonesiaThere is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm 3 at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success.https://doi.org/10.1177/2325958219899534 |
| spellingShingle | Suzy Maria MD Evy Yunihastuti MD, PhD Siti Rizny F. Saldi MSc Zubairi Djoerban MD Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption Journal of the International Association of Providers of AIDS Care |
| title | Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption |
| title_full | Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption |
| title_fullStr | Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption |
| title_full_unstemmed | Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption |
| title_short | Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption |
| title_sort | factors affecting virological outcome when first line antiretroviral therapy is reintroduced after unplanned interruption |
| url | https://doi.org/10.1177/2325958219899534 |
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