Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital
Further reduction of mother-to-child transmission (MTCT) of HIV requires improved understanding of the reasons for MTCT. We reviewed maternal and infant case notes for HIV- positive infants diagnosed by polymerase chain reaction at Bethesda Hospital. Nineteen cases were analysed. Median gestation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AOSIS
2015-04-01
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| Series: | Southern African Journal of HIV Medicine |
| Online Access: | https://sajhivmed.org.za/index.php/hivmed/article/view/365 |
| _version_ | 1818008947438649344 |
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| author | Clifford Kendall Lore Claessens Jienchi Dorward Gloria Mfeka Kelly Gate |
| author_facet | Clifford Kendall Lore Claessens Jienchi Dorward Gloria Mfeka Kelly Gate |
| author_sort | Clifford Kendall |
| collection | DOAJ |
| description | Further reduction of mother-to-child transmission (MTCT) of HIV requires improved understanding of the reasons for MTCT. We reviewed maternal and infant case notes for HIV- positive infants diagnosed by polymerase chain reaction at Bethesda Hospital. Nineteen cases were analysed. Median gestation at first antenatal consultation (ANC) was 22.5 (interquartile range [IQR] 19.25–24). Eleven (57.9%) mothers were HIV positive at first ANC, whilst eight tested negative and later positive (2 antepartum, 6 postpartum). Median maternal CD4 was 408 cells/μL (IQR 318–531). Six (31.6%) received no antenatal antiretroviral therapy (ART) because they were diagnosed as HIV positive postpartum; 9 (47.3%) received antenatal ART and 3 (15.8%) were never initiated on ART. At 6 weeks postpartum, 5 infants (26.3%) were not on prophylactic nevirapine (NVP) because their mothers had not yet been diagnosed. Maternal seroconversion in pregnancy and breastfeeding, and possibly false-negative HIV tests, were important reasons for prevention of mother-to-child transmission (PMTCT) failure. |
| first_indexed | 2024-04-14T05:36:51Z |
| format | Article |
| id | doaj.art-a6250db06ccc4147a2d6206005bd7541 |
| institution | Directory Open Access Journal |
| issn | 1608-9693 2078-6751 |
| language | English |
| last_indexed | 2024-04-14T05:36:51Z |
| publishDate | 2015-04-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of HIV Medicine |
| spelling | doaj.art-a6250db06ccc4147a2d6206005bd75412022-12-22T02:09:37ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512015-04-01161e1e310.4102/sajhivmed.v16i1.365321Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospitalClifford Kendall0Lore Claessens1Jienchi Dorward2Gloria Mfeka3Kelly Gate4Bethesda Hospital, Umkhanyakude District, KwaZulu-Natal20,000 Plus Partnership, University of KwaZulu-NatalBethesda Hospital, Umkhanyakude District, KwaZulu-NatalBethesda Hospital, Umkhanyakude District, KwaZulu-Natal; Departmentof Family Medicine, University of KwaZulu-NatalBethesda Hospital, Umkhanyakude District, KwaZulu-Natal; Departmentof Family Medicine, University of KwaZulu-NatalFurther reduction of mother-to-child transmission (MTCT) of HIV requires improved understanding of the reasons for MTCT. We reviewed maternal and infant case notes for HIV- positive infants diagnosed by polymerase chain reaction at Bethesda Hospital. Nineteen cases were analysed. Median gestation at first antenatal consultation (ANC) was 22.5 (interquartile range [IQR] 19.25–24). Eleven (57.9%) mothers were HIV positive at first ANC, whilst eight tested negative and later positive (2 antepartum, 6 postpartum). Median maternal CD4 was 408 cells/μL (IQR 318–531). Six (31.6%) received no antenatal antiretroviral therapy (ART) because they were diagnosed as HIV positive postpartum; 9 (47.3%) received antenatal ART and 3 (15.8%) were never initiated on ART. At 6 weeks postpartum, 5 infants (26.3%) were not on prophylactic nevirapine (NVP) because their mothers had not yet been diagnosed. Maternal seroconversion in pregnancy and breastfeeding, and possibly false-negative HIV tests, were important reasons for prevention of mother-to-child transmission (PMTCT) failure.https://sajhivmed.org.za/index.php/hivmed/article/view/365 |
| spellingShingle | Clifford Kendall Lore Claessens Jienchi Dorward Gloria Mfeka Kelly Gate Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital Southern African Journal of HIV Medicine |
| title | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital |
| title_full | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital |
| title_fullStr | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital |
| title_full_unstemmed | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital |
| title_short | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital |
| title_sort | reasons for failure of prevention of mother to child hiv transmission in a rural south african district hospital |
| url | https://sajhivmed.org.za/index.php/hivmed/article/view/365 |
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