Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn
The article offers dataset on the expression of serotonergic nerve in the hippocampal area of Alzheimer's disease (AD) model. Since decreasing expression of serotonin linked to dementia, this data will help the neuroscientist, who work on neurodegeneration. This dataset demonstrates the potenti...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920305485 |
| _version_ | 1828954902970236928 |
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| author | M. Nova Raditya A.M. Made Bagus Ulayatul Kustiati Hevi Wihadmadyatami Dwi Liliek Kusindarta |
| author_facet | M. Nova Raditya A.M. Made Bagus Ulayatul Kustiati Hevi Wihadmadyatami Dwi Liliek Kusindarta |
| author_sort | M. Nova Raditya |
| collection | DOAJ |
| description | The article offers dataset on the expression of serotonergic nerve in the hippocampal area of Alzheimer's disease (AD) model. Since decreasing expression of serotonin linked to dementia, this data will help the neuroscientist, who work on neurodegeneration. This dataset demonstrates the potential of Ocimum sanctum Extract (OSE) as a neuroprotective and neurodegenerative agent against AD. The OSE mechanism focusing on the expression of serotonin as a therapeutic target. To acquire the dataset, we approached using two models, in vitro and in vivo. On the In vivo model, used two months old 27 male rats and divided into three groups, non-treated (Group A, n=9), AD rats model pre-treated with OSE followed induction for TMT on the days of seventh (group B, n=9) and AD rats model treated with OSE both on pre-TMT introduction for seven days and post-TMT induction for 21 days (group C, n=9). AD rats euthanised on day seventh; 14th; and 21st. The brain samples were analysed for neuronal density and serotonin immunoreactivity qualitatively. Besides, In Vitro's data were collected from HEK-293 cells which induce by TMT as of AD model. The data expression of serotonin on the in-vitro model analysed using ELISA method. |
| first_indexed | 2024-12-14T07:38:14Z |
| format | Article |
| id | doaj.art-a6274901cc754705ae9c7cd53eb129d6 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-14T07:38:14Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-a6274901cc754705ae9c7cd53eb129d62022-12-21T23:11:06ZengElsevierData in Brief2352-34092020-06-0130105654Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum LinnM. Nova Raditya0A.M. Made Bagus1Ulayatul Kustiati2Hevi Wihadmadyatami3Dwi Liliek Kusindarta4Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaIntegrated Laboratory for Research and Testing, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartment of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartment of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartment of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia; Corresponding author.The article offers dataset on the expression of serotonergic nerve in the hippocampal area of Alzheimer's disease (AD) model. Since decreasing expression of serotonin linked to dementia, this data will help the neuroscientist, who work on neurodegeneration. This dataset demonstrates the potential of Ocimum sanctum Extract (OSE) as a neuroprotective and neurodegenerative agent against AD. The OSE mechanism focusing on the expression of serotonin as a therapeutic target. To acquire the dataset, we approached using two models, in vitro and in vivo. On the In vivo model, used two months old 27 male rats and divided into three groups, non-treated (Group A, n=9), AD rats model pre-treated with OSE followed induction for TMT on the days of seventh (group B, n=9) and AD rats model treated with OSE both on pre-TMT introduction for seven days and post-TMT induction for 21 days (group C, n=9). AD rats euthanised on day seventh; 14th; and 21st. The brain samples were analysed for neuronal density and serotonin immunoreactivity qualitatively. Besides, In Vitro's data were collected from HEK-293 cells which induce by TMT as of AD model. The data expression of serotonin on the in-vitro model analysed using ELISA method.http://www.sciencedirect.com/science/article/pii/S2352340920305485Neurodegenerative diseaseHippocampalSerotoninOcimum sanctum Linn. Ethanolic extract |
| spellingShingle | M. Nova Raditya A.M. Made Bagus Ulayatul Kustiati Hevi Wihadmadyatami Dwi Liliek Kusindarta Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn Data in Brief Neurodegenerative disease Hippocampal Serotonin Ocimum sanctum Linn. Ethanolic extract |
| title | Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn |
| title_full | Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn |
| title_fullStr | Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn |
| title_full_unstemmed | Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn |
| title_short | Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn |
| title_sort | data of the expression of serotonin in alzheimer s disease ad rat model under treatment of ethanolic extract ocimum sanctum linn |
| topic | Neurodegenerative disease Hippocampal Serotonin Ocimum sanctum Linn. Ethanolic extract |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920305485 |
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