Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy

Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy

Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resectio...

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Bibliographic Details
Main Authors: William L. Harryman, Jaime M.C. Gard, Kelvin W. Pond, Skyler J. Simpson, Lucas H. Heppner, Daniel Hernandez-Cortes, Andrew S. Little, Jennifer M. Eschbacher, Anne E. Cress
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558617301872

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