Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication
Clonidine has been shown to reduce perioperative haemodynamic instability. The aim of the study was to investigate the clinical efficiency of oral clonidine premedication in prevention of haemodynamic response associated with pneumoperitoneum. Sixty adult patients of ASA physical status I& II, s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=3;spage=205;epage=210;aulast=Das |
| _version_ | 1819150528651722752 |
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| author | Mrinmoy Das Manjushree Ray Gauri Mukherjee |
| author_facet | Mrinmoy Das Manjushree Ray Gauri Mukherjee |
| author_sort | Mrinmoy Das |
| collection | DOAJ |
| description | Clonidine has been shown to reduce perioperative haemodynamic instability. The aim of the study was to investigate the clinical efficiency of oral clonidine premedication in prevention of haemodynamic response associated with pneumoperitoneum.
Sixty adult patients of ASA physical status I& II, scheduled for elective laparoscopic cholecystectomy were recruited for a prospective randomized, double-blinded comparative study. They were randomly allocated to one of the two groups to receive either oral clonidine 150 gg (Group C) or ranitidine 150 mg (Group P), 90 minute before induction of anaesthesia.
Significant rise in heart rate was observed following pneumoperitoneum in Group P as compared to Group C (99.23±14.02 Vs 81.26±8.40 bpm). Similarly, rise in systolic arterial pressure (143.63±19.60 Vs 119.6±10.06 mm Hg), diastolic arterial pressure (99.23±14.02 Vs 81.26±8.40 mm Hg) and mean arterial pressure (114.13±16.57 Vs 93.83±8.107 mm Hg) was more in Group P following pneumoperitoneum. Nitroglycerine drip was started in 33.3% patients in Group P to control intraoperative hypertension. Incidence of postopera-tive nausea-vomiting and shivering was also less in Group C.
To conclude, clonidine premedication provides perioperative haemodynamic stability, hence it can be recommended as a routine premedication for laparoscopic procedure. |
| first_indexed | 2024-12-22T14:18:56Z |
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| id | doaj.art-a629b59fece5413c977c7a7ff16f90e6 |
| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-22T14:18:56Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-a629b59fece5413c977c7a7ff16f90e62022-12-21T18:23:02ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492007-01-01513205210Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedicationMrinmoy DasManjushree RayGauri MukherjeeClonidine has been shown to reduce perioperative haemodynamic instability. The aim of the study was to investigate the clinical efficiency of oral clonidine premedication in prevention of haemodynamic response associated with pneumoperitoneum. Sixty adult patients of ASA physical status I& II, scheduled for elective laparoscopic cholecystectomy were recruited for a prospective randomized, double-blinded comparative study. They were randomly allocated to one of the two groups to receive either oral clonidine 150 gg (Group C) or ranitidine 150 mg (Group P), 90 minute before induction of anaesthesia. Significant rise in heart rate was observed following pneumoperitoneum in Group P as compared to Group C (99.23±14.02 Vs 81.26±8.40 bpm). Similarly, rise in systolic arterial pressure (143.63±19.60 Vs 119.6±10.06 mm Hg), diastolic arterial pressure (99.23±14.02 Vs 81.26±8.40 mm Hg) and mean arterial pressure (114.13±16.57 Vs 93.83±8.107 mm Hg) was more in Group P following pneumoperitoneum. Nitroglycerine drip was started in 33.3% patients in Group P to control intraoperative hypertension. Incidence of postopera-tive nausea-vomiting and shivering was also less in Group C. To conclude, clonidine premedication provides perioperative haemodynamic stability, hence it can be recommended as a routine premedication for laparoscopic procedure.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=3;spage=205;epage=210;aulast=DasLaparoscopic cholecystectomy; PneumoperitoneumHaemodynamic response; Clonidine premedication. |
| spellingShingle | Mrinmoy Das Manjushree Ray Gauri Mukherjee Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication Indian Journal of Anaesthesia Laparoscopic cholecystectomy; Pneumoperitoneum Haemodynamic response; Clonidine premedication. |
| title | Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication |
| title_full | Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication |
| title_fullStr | Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication |
| title_full_unstemmed | Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication |
| title_short | Haemodynamic changes during laparoscopic cholccystectomy: Effect of clonidine premedication |
| title_sort | haemodynamic changes during laparoscopic cholccystectomy effect of clonidine premedication |
| topic | Laparoscopic cholecystectomy; Pneumoperitoneum Haemodynamic response; Clonidine premedication. |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=3;spage=205;epage=210;aulast=Das |
| work_keys_str_mv | AT mrinmoydas haemodynamicchangesduringlaparoscopiccholccystectomyeffectofclonidinepremedication AT manjushreeray haemodynamicchangesduringlaparoscopiccholccystectomyeffectofclonidinepremedication AT gaurimukherjee haemodynamicchangesduringlaparoscopiccholccystectomyeffectofclonidinepremedication |