The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?
Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several ri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1358179/full |
| _version_ | 1797336124346073088 |
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| author | Ruohan Li Junnan Wang Wei Xiong Yu Luo Yu Luo Huixian Feng Heng Zhou Youjian Peng Yan He Qingsong Ye Qingsong Ye |
| author_facet | Ruohan Li Junnan Wang Wei Xiong Yu Luo Yu Luo Huixian Feng Heng Zhou Youjian Peng Yan He Qingsong Ye Qingsong Ye |
| author_sort | Ruohan Li |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis is an inflammatory disease triggered by dysbiosis of oral microorganisms, whereas Alzheimer’s disease is characterized by neuroinflammation. Many studies have indicated that chronic inflammation can instigate brain AD-related pathologies, including amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, and neurodegeneration. The potential involvement of periodontal pathogens and/or their virulence factors in the onset and progression of AD by the oral-brain axis has garnered significant attention among researchers with ongoing investigations. This review has updated the periodontal pathogens potentially associated with AD, elucidating their impact on the central nervous system, immune response, and related pathological processes in the brain to provide valuable insights for future research on the oral-brain axis. |
| first_indexed | 2024-03-08T08:48:34Z |
| format | Article |
| id | doaj.art-a62eb4bd81a74617b73728e0abcc521d |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T08:48:34Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a62eb4bd81a74617b73728e0abcc521d2024-02-01T13:33:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-02-011510.3389/fmicb.2024.13581791358179The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?Ruohan Li0Junnan Wang1Wei Xiong2Yu Luo3Yu Luo4Huixian Feng5Heng Zhou6Youjian Peng7Yan He8Qingsong Ye9Qingsong Ye10Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Stomatology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Stomatology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Stomatology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaInstitute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Stomatology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaAlzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis is an inflammatory disease triggered by dysbiosis of oral microorganisms, whereas Alzheimer’s disease is characterized by neuroinflammation. Many studies have indicated that chronic inflammation can instigate brain AD-related pathologies, including amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, and neurodegeneration. The potential involvement of periodontal pathogens and/or their virulence factors in the onset and progression of AD by the oral-brain axis has garnered significant attention among researchers with ongoing investigations. This review has updated the periodontal pathogens potentially associated with AD, elucidating their impact on the central nervous system, immune response, and related pathological processes in the brain to provide valuable insights for future research on the oral-brain axis.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1358179/fullAlzheimer’s diseaseperiodontal pathogenneuroinflammationperiodontitisneurodegeneration |
| spellingShingle | Ruohan Li Junnan Wang Wei Xiong Yu Luo Yu Luo Huixian Feng Heng Zhou Youjian Peng Yan He Qingsong Ye Qingsong Ye The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? Frontiers in Microbiology Alzheimer’s disease periodontal pathogen neuroinflammation periodontitis neurodegeneration |
| title | The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? |
| title_full | The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? |
| title_fullStr | The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? |
| title_full_unstemmed | The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? |
| title_short | The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease? |
| title_sort | oral brain axis can periodontal pathogens trigger the onset and progression of alzheimer s disease |
| topic | Alzheimer’s disease periodontal pathogen neuroinflammation periodontitis neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1358179/full |
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