Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats
Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of dru...
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| Format: | Article |
| Language: | English |
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Indian Council of Agricultural Research
2016-07-01
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| Series: | Indian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/59884 |
| _version_ | 1797742049480409088 |
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| author | RAJKUMAR SINGH YADAV SATISH KUMAR GARG |
| author_facet | RAJKUMAR SINGH YADAV SATISH KUMAR GARG |
| author_sort | RAJKUMAR SINGH YADAV |
| collection | DOAJ |
| description |
Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of drug administration and peaked at 1 h. t1/2ka and t1/2β values were 13.59 and 78.41 min after i.m. administration while 17.89 and 103.59 min after s.c. administration and the corresponding bioavailability values were 75.43±5.00 and 102.07±7.00 %. Ofloxacin may be adiministered to goat @10 mg/kg at 12 h interval by s.c. route.
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| first_indexed | 2024-03-12T14:35:27Z |
| format | Article |
| id | doaj.art-a62ecf97739545f482e3639d5f3e8d08 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-03-12T14:35:27Z |
| publishDate | 2016-07-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-a62ecf97739545f482e3639d5f3e8d082023-08-17T09:10:39ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272016-07-0186710.56093/ijans.v86i7.59884Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goatsRAJKUMAR SINGH YADAV0SATISH KUMAR GARG1UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya evam Go- Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh 281 001 IndiaUP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya evam Go- Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh 281 001 India Comparative disposition kinetics of ofloxacin following intramuscular (i.m.) and subcutaneous (s.c.) administration was studied in goats @ 10 mg/kg. Ofloxacin was determined by HPLC method and kinetic parameters using a software. Appreciable plasma concentrations were observed within 2.5 min of drug administration and peaked at 1 h. t1/2ka and t1/2β values were 13.59 and 78.41 min after i.m. administration while 17.89 and 103.59 min after s.c. administration and the corresponding bioavailability values were 75.43±5.00 and 102.07±7.00 %. Ofloxacin may be adiministered to goat @10 mg/kg at 12 h interval by s.c. route. https://epubs.icar.org.in/index.php/IJAnS/article/view/59884BioavailabilityGoatsIntramuscularOfloxacinSubcutaneous |
| spellingShingle | RAJKUMAR SINGH YADAV SATISH KUMAR GARG Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats Indian Journal of Animal Sciences Bioavailability Goats Intramuscular Ofloxacin Subcutaneous |
| title | Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| title_full | Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| title_fullStr | Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| title_full_unstemmed | Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| title_short | Pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| title_sort | pharmacokinetics and bioavailability of ofloxacin following single intramuscular and subcutaneous administration in goats |
| topic | Bioavailability Goats Intramuscular Ofloxacin Subcutaneous |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/59884 |
| work_keys_str_mv | AT rajkumarsinghyadav pharmacokineticsandbioavailabilityofofloxacinfollowingsingleintramuscularandsubcutaneousadministrationingoats AT satishkumargarg pharmacokineticsandbioavailabilityofofloxacinfollowingsingleintramuscularandsubcutaneousadministrationingoats |