Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β
The authors revealed novel roles of catalytic residues and divalent metal ions for hsTOP3B, the human RNA topoisomerase, and demonstrated the structural elements that kinetically modulate the DNA and RNA topoisomerase activities of TOP3B.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32221-3 |
| _version_ | 1828154146049490944 |
|---|---|
| author | Xi Yang Sourav Saha Wei Yang Keir C. Neuman Yves Pommier |
| author_facet | Xi Yang Sourav Saha Wei Yang Keir C. Neuman Yves Pommier |
| author_sort | Xi Yang |
| collection | DOAJ |
| description | The authors revealed novel roles of catalytic residues and divalent metal ions for hsTOP3B, the human RNA topoisomerase, and demonstrated the structural elements that kinetically modulate the DNA and RNA topoisomerase activities of TOP3B. |
| first_indexed | 2024-04-11T22:36:00Z |
| format | Article |
| id | doaj.art-a62f3f182d8847f38bd06bce5d1e33e8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T22:36:00Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a62f3f182d8847f38bd06bce5d1e33e82022-12-22T03:59:13ZengNature PortfolioNature Communications2041-17232022-08-0113111410.1038/s41467-022-32221-3Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3βXi Yang0Sourav Saha1Wei Yang2Keir C. Neuman3Yves Pommier4Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHDevelopmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIHLaboratory of Single Molecule Biophysics, National Heart, Lung and Blood Institute, National Institutes of HealthDevelopmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHThe authors revealed novel roles of catalytic residues and divalent metal ions for hsTOP3B, the human RNA topoisomerase, and demonstrated the structural elements that kinetically modulate the DNA and RNA topoisomerase activities of TOP3B.https://doi.org/10.1038/s41467-022-32221-3 |
| spellingShingle | Xi Yang Sourav Saha Wei Yang Keir C. Neuman Yves Pommier Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β Nature Communications |
| title | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β |
| title_full | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β |
| title_fullStr | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β |
| title_full_unstemmed | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β |
| title_short | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β |
| title_sort | structural and biochemical basis for dna and rna catalysis by human topoisomerase 3β |
| url | https://doi.org/10.1038/s41467-022-32221-3 |
| work_keys_str_mv | AT xiyang structuralandbiochemicalbasisfordnaandrnacatalysisbyhumantopoisomerase3b AT souravsaha structuralandbiochemicalbasisfordnaandrnacatalysisbyhumantopoisomerase3b AT weiyang structuralandbiochemicalbasisfordnaandrnacatalysisbyhumantopoisomerase3b AT keircneuman structuralandbiochemicalbasisfordnaandrnacatalysisbyhumantopoisomerase3b AT yvespommier structuralandbiochemicalbasisfordnaandrnacatalysisbyhumantopoisomerase3b |