Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study
Abstract Background Many studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings. Methods A prospective census-based cohort study was conducted in Qingdao, China, from August...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-021-11034-x |
| _version_ | 1819149931643928576 |
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| author | Xiao Jin Wei Ni Guolan Wang Qin Wu Jun Zhang Guoju Li Na Jiao Wenjing Chen Qing Liu Li Gao Quansheng Xing |
| author_facet | Xiao Jin Wei Ni Guolan Wang Qin Wu Jun Zhang Guoju Li Na Jiao Wenjing Chen Qing Liu Li Gao Quansheng Xing |
| author_sort | Xiao Jin |
| collection | DOAJ |
| description | Abstract Background Many studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings. Methods A prospective census-based cohort study was conducted in Qingdao, China, from August 1, 2018 to April 30, 2019. All of the local registered pregnant women were continuously investigated and followed from 15 to 20 weeks of gestation to delivery, tracking the CHD cases in both the fetal and neonatal stages. A logistic regression model was applied to assess the association between CHD and possible risk factors. Results The positive rate of prenatal CHD screening was 14.36 per 1000 fetuses and the incidence of CHD was 9.38 per 1000 live births. Results from logistic regression indicated that, living in the countryside (odds ratio, (OR): 0.771; 95% confidence interval, (CI): 0.628–0.946) and having a childbearing history (OR: 0.802; 95%CI: 0.676–0.951) were negatively associated with CHD. However, twin pregnancy (OR: 1.957, 95% CI: 1.245–3.076), illness in the first trimester (OR: 1.306; 95% CI: 1.048–1.628), a family history of CHD (OR: 7.156; 95% CI: 3.293–15.552), and having a child with a birth defect (OR: 2.086; 95% CI: 1.167–3.731) were positively associated with CHD. Conclusion CHD is a serious health problem in Qingdao. The CHD incidence found in this study was similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Moreover, CHD risk factors were identified in our study, and our findings may have great implications for formation CHD intervention strategies. |
| first_indexed | 2024-12-22T14:09:27Z |
| format | Article |
| id | doaj.art-a62f67cb6558426b814575546d7d28ed |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-22T14:09:27Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-a62f67cb6558426b814575546d7d28ed2022-12-21T18:23:13ZengBMCBMC Public Health1471-24582021-06-0121111010.1186/s12889-021-11034-xIncidence and risk factors of congenital heart disease in Qingdao: a prospective cohort studyXiao Jin0Wei Ni1Guolan Wang2Qin Wu3Jun Zhang4Guoju Li5Na Jiao6Wenjing Chen7Qing Liu8Li Gao9Quansheng Xing10Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityQingdao Maternal and Child Health Care and Family Planning Service Center, Qingdao UniversityQingdao Maternal and Child Health Care and Family Planning Service Center, Qingdao UniversityQingdao Maternal and Child Health Care and Family Planning Service Center, Qingdao UniversityQingdao Women and Children’s Hospital, Qingdao UniversityAbstract Background Many studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings. Methods A prospective census-based cohort study was conducted in Qingdao, China, from August 1, 2018 to April 30, 2019. All of the local registered pregnant women were continuously investigated and followed from 15 to 20 weeks of gestation to delivery, tracking the CHD cases in both the fetal and neonatal stages. A logistic regression model was applied to assess the association between CHD and possible risk factors. Results The positive rate of prenatal CHD screening was 14.36 per 1000 fetuses and the incidence of CHD was 9.38 per 1000 live births. Results from logistic regression indicated that, living in the countryside (odds ratio, (OR): 0.771; 95% confidence interval, (CI): 0.628–0.946) and having a childbearing history (OR: 0.802; 95%CI: 0.676–0.951) were negatively associated with CHD. However, twin pregnancy (OR: 1.957, 95% CI: 1.245–3.076), illness in the first trimester (OR: 1.306; 95% CI: 1.048–1.628), a family history of CHD (OR: 7.156; 95% CI: 3.293–15.552), and having a child with a birth defect (OR: 2.086; 95% CI: 1.167–3.731) were positively associated with CHD. Conclusion CHD is a serious health problem in Qingdao. The CHD incidence found in this study was similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Moreover, CHD risk factors were identified in our study, and our findings may have great implications for formation CHD intervention strategies.https://doi.org/10.1186/s12889-021-11034-xEpidemiologic studiesCongenital heart defectsIncidenceRegression analysisRisk factors |
| spellingShingle | Xiao Jin Wei Ni Guolan Wang Qin Wu Jun Zhang Guoju Li Na Jiao Wenjing Chen Qing Liu Li Gao Quansheng Xing Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study BMC Public Health Epidemiologic studies Congenital heart defects Incidence Regression analysis Risk factors |
| title | Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study |
| title_full | Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study |
| title_fullStr | Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study |
| title_full_unstemmed | Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study |
| title_short | Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study |
| title_sort | incidence and risk factors of congenital heart disease in qingdao a prospective cohort study |
| topic | Epidemiologic studies Congenital heart defects Incidence Regression analysis Risk factors |
| url | https://doi.org/10.1186/s12889-021-11034-x |
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