SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study
Abstract Background Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one of the most pleiotropic single nucleotide polymorphisms (SNPs) in SLC...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2240-2 |
| _version_ | 1818334681434685440 |
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| author | Xuemin Jian Jianhua Chen Zhiqiang Li Zhijian Song Juan Zhou Wei Xu Yahui Liu Jiawei Shen Yonggang Wang Qizhong Yi Yongyong Shi |
| author_facet | Xuemin Jian Jianhua Chen Zhiqiang Li Zhijian Song Juan Zhou Wei Xu Yahui Liu Jiawei Shen Yonggang Wang Qizhong Yi Yongyong Shi |
| author_sort | Xuemin Jian |
| collection | DOAJ |
| description | Abstract Background Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one of the most pleiotropic single nucleotide polymorphisms (SNPs) in SLC39A8, rs13107325, is associated with schizophrenia in the European population. However, the polymorphism of this locus is rare in other populations. In China, the Han Chinese and the Uygur Chinese are two ethnic populations that originate from different races. Methods A case-control study was conducted with 983 schizophrenia cases and 1230 healthy controls of the Chinese Uygur population. To validate the most promising SNP, meta-analyses were conducted with the Han Chinese and the European PGC2 data sets reported previously. Results A susceptible locus, rs10014145 (p allele = 0.014, p allele = 0.098 after correction; p genotype = 0.004, p genotype = 0.032 after correction) was identified in case-control study of the Chinese Uygur population. Further, the association between rs10014145 and schizophrenia was supported by a meta-analysis of Han and Uygur Chinese samples (pooled OR [95% CI] =1.10 [1.03–1.17], Z = 2.73, p = 0.006). The association between rs10014145 and schizophrenia was not significant in a meta-analysis of combined Chinese and European samples (pooled OR [95% CI] =1.07 [1.00–1.14], Z = 1.88, and p = 0.06). In addition, the “CCAC” haplotype of rs4698844-rs233814-rs13114343-rs151394 was significantly associated with schizophrenia in Uygur Chinese (P = 0.003, corrected p = 0.012). Conclusions The results of this study support that SLC39A8 is a susceptible gene for schizophrenia in the populations of Han Chinese and Uygur Chinese in China, further studies are suggested to validate the association. |
| first_indexed | 2024-12-13T14:11:24Z |
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| id | doaj.art-a630566281d8487db748d30f0bcc3dff |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-13T14:11:24Z |
| publishDate | 2019-09-01 |
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| spelling | doaj.art-a630566281d8487db748d30f0bcc3dff2022-12-21T23:42:27ZengBMCBMC Psychiatry1471-244X2019-09-011911910.1186/s12888-019-2240-2SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control studyXuemin Jian0Jianhua Chen1Zhiqiang Li2Zhijian Song3Juan Zhou4Wei Xu5Yahui Liu6Jiawei Shen7Yonggang Wang8Qizhong Yi9Yongyong Shi10Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityDepartment of Neurology, School of Medicine, Renji Hospital, Shanghai Jiao Tong UniversityPsychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical UniversityBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong UniversityAbstract Background Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one of the most pleiotropic single nucleotide polymorphisms (SNPs) in SLC39A8, rs13107325, is associated with schizophrenia in the European population. However, the polymorphism of this locus is rare in other populations. In China, the Han Chinese and the Uygur Chinese are two ethnic populations that originate from different races. Methods A case-control study was conducted with 983 schizophrenia cases and 1230 healthy controls of the Chinese Uygur population. To validate the most promising SNP, meta-analyses were conducted with the Han Chinese and the European PGC2 data sets reported previously. Results A susceptible locus, rs10014145 (p allele = 0.014, p allele = 0.098 after correction; p genotype = 0.004, p genotype = 0.032 after correction) was identified in case-control study of the Chinese Uygur population. Further, the association between rs10014145 and schizophrenia was supported by a meta-analysis of Han and Uygur Chinese samples (pooled OR [95% CI] =1.10 [1.03–1.17], Z = 2.73, p = 0.006). The association between rs10014145 and schizophrenia was not significant in a meta-analysis of combined Chinese and European samples (pooled OR [95% CI] =1.07 [1.00–1.14], Z = 1.88, and p = 0.06). In addition, the “CCAC” haplotype of rs4698844-rs233814-rs13114343-rs151394 was significantly associated with schizophrenia in Uygur Chinese (P = 0.003, corrected p = 0.012). Conclusions The results of this study support that SLC39A8 is a susceptible gene for schizophrenia in the populations of Han Chinese and Uygur Chinese in China, further studies are suggested to validate the association.http://link.springer.com/article/10.1186/s12888-019-2240-2SLC39A8SchizophreniaCase-control studyMeta-analysisUygur Chinese |
| spellingShingle | Xuemin Jian Jianhua Chen Zhiqiang Li Zhijian Song Juan Zhou Wei Xu Yahui Liu Jiawei Shen Yonggang Wang Qizhong Yi Yongyong Shi SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study BMC Psychiatry SLC39A8 Schizophrenia Case-control study Meta-analysis Uygur Chinese |
| title | SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study |
| title_full | SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study |
| title_fullStr | SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study |
| title_full_unstemmed | SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study |
| title_short | SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study |
| title_sort | slc39a8 is a risk factor for schizophrenia in uygur chinese a case control study |
| topic | SLC39A8 Schizophrenia Case-control study Meta-analysis Uygur Chinese |
| url | http://link.springer.com/article/10.1186/s12888-019-2240-2 |
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