A mechanistic tumor penetration model to guide antibody drug conjugate design.

A mechanistic tumor penetration model to guide antibody drug conjugate design.

Antibody drug conjugates (ADCs) represent novel anti-cancer modalities engineered to specifically target and kill tumor cells expressing corresponding antigens. Due to their large size and their complex kinetics, these therapeutic agents often face heterogeneous distributions in tumors, leading to l...

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Bibliographic Details
Main Authors: Christina Vasalou, Gabriel Helmlinger, Bruce Gomes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4364906?pdf=render

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