EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
We have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and ad...
| Glavni autori: | , , , , , |
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| Format: | Članak |
| Jezik: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Serija: | Медицинская иммунология |
| Teme: | |
| Online pristup: | https://www.mimmun.ru/mimmun/article/view/356 |
| _version_ | 1826534339492446208 |
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| author | A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev |
| author_facet | A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev |
| author_sort | A. V. Zurochka |
| collection | DOAJ |
| description | We have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and adolescents, as amended by CDC (USA). It was revealed that, at each subsequent stage of disease, a decrease in absolute numbers of T-helpers is accompanied by drop in relative and absolute numbers of lymphocytes, as well as in total T-lymphocyte numbers, and decreased amounts of absolute cytotoxic T-lymphocytes levels, combined with increase in their relative contents, along with decreased CD3+CD4+/CD3+CD8+ ratio, diminished levels of double-positive subpopulation, decrease in relative and absolute levels of αβТ-lymphocytes and significant drop in absolute levels of γδТ-cells, while their relative amounts remained normal. These findings demonstrate a pattern typical to the absence of immunological reactions in response to antigens persisting in the organism. |
| first_indexed | 2024-03-08T05:50:54Z |
| format | Article |
| id | doaj.art-a6318d2b33054418993008c900caa6d9 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:27Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a6318d2b33054418993008c900caa6d92025-03-11T17:59:02ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01124-542542810.15789/1563-0625-2010-4-5-425-428353EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTSA. V. Zurochka0T. V. Gavrilova1E. V. Shestakova2S. V. Kvyatkovskaya3T. V. Mirkina4V. A. Chereshnev5Самостоятельный курс клинической лабораторной диагностики ГОУ ВПО ЧелГМА Росздрава, г. ЧелябинскПермская государственная медицинская академия имени академика Е.А. Вагнера, г. ПермьКлиника ГОУ ВПО ЧелГМА Росздрава, Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями, г. ЧелябинскКлиника ГОУ ВПО ЧелГМА Росздрава, Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями, г. ЧелябинскКлиника ГОУ ВПО ЧелГМА Росздрава, Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями, г. ЧелябинскУчреждение РАН НИИ иммунологии и физиологии Уро РАН, г. ЕкатеринбургWe have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and adolescents, as amended by CDC (USA). It was revealed that, at each subsequent stage of disease, a decrease in absolute numbers of T-helpers is accompanied by drop in relative and absolute numbers of lymphocytes, as well as in total T-lymphocyte numbers, and decreased amounts of absolute cytotoxic T-lymphocytes levels, combined with increase in their relative contents, along with decreased CD3+CD4+/CD3+CD8+ ratio, diminished levels of double-positive subpopulation, decrease in relative and absolute levels of αβТ-lymphocytes and significant drop in absolute levels of γδТ-cells, while their relative amounts remained normal. These findings demonstrate a pattern typical to the absence of immunological reactions in response to antigens persisting in the organism.https://www.mimmun.ru/mimmun/article/view/356тγδ-lymphocyteshiv infectionhelper т cellscytotoxic t lymphocytesimmunophenotyping |
| spellingShingle | A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS Медицинская иммунология тγδ-lymphocytes hiv infection helper т cells cytotoxic t lymphocytes immunophenotyping |
| title | EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS |
| title_full | EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS |
| title_fullStr | EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS |
| title_full_unstemmed | EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS |
| title_short | EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS |
| title_sort | evaluation of interdependence between γδt cell levels and cd3 cd4 t lymphocyte contents in hiv infected patients |
| topic | тγδ-lymphocytes hiv infection helper т cells cytotoxic t lymphocytes immunophenotyping |
| url | https://www.mimmun.ru/mimmun/article/view/356 |
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