IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of L...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11147-3 |
| _version_ | 1818684827832942592 |
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| author | Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv |
| author_facet | Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv |
| author_sort | Kyuho Kang |
| collection | DOAJ |
| description | Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of LPS signaling. |
| first_indexed | 2024-12-17T10:56:49Z |
| format | Article |
| id | doaj.art-a631a2760ed54421b4271c48a107d9ac |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:56:49Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a631a2760ed54421b4271c48a107d9ac2022-12-21T21:51:47ZengNature PortfolioNature Communications2041-17232019-07-0110111410.1038/s41467-019-11147-3IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activationKyuho Kang0Mahesh Bachu1Sung Ho Park2Keunsoo Kang3Seyeon Bae4Kyung-Hyun Park-Min5Lionel B. Ivashkiv6Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryDepartment of Microbiology, Dankook UniversityArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special SurgeryMacrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of LPS signaling.https://doi.org/10.1038/s41467-019-11147-3 |
| spellingShingle | Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation Nature Communications |
| title | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation |
| title_full | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation |
| title_fullStr | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation |
| title_full_unstemmed | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation |
| title_short | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation |
| title_sort | ifn γ selectively suppresses a subset of tlr4 activated genes and enhancers to potentiate macrophage activation |
| url | https://doi.org/10.1038/s41467-019-11147-3 |
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