Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/7/725 |
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| author | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Jorge Rodríguez-Jiménez Victor Gómez-Mayordomo Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen Juan Torres-Macho |
| author_facet | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Jorge Rodríguez-Jiménez Victor Gómez-Mayordomo Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen Juan Torres-Macho |
| author_sort | César Fernández-de-las-Peñas |
| collection | DOAJ |
| description | This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (<i>p</i> < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (<i>p</i> < 0.01). The mean number of post-COVID-19 symptoms was higher (<i>p</i> < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (<i>p</i> < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (<i>p</i> = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (<i>p</i> = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants. |
| first_indexed | 2024-03-09T13:13:29Z |
| format | Article |
| id | doaj.art-a6338b222556405886d23a6ca1d45929 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T13:13:29Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-a6338b222556405886d23a6ca1d459292023-11-30T21:38:53ZengMDPI AGPathogens2076-08172022-06-0111772510.3390/pathogens11070725Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 VariantCésar Fernández-de-las-Peñas0Ignacio Cancela-Cilleruelo1Jorge Rodríguez-Jiménez2Victor Gómez-Mayordomo3Oscar J. Pellicer-Valero4José D. Martín-Guerrero5Valentín Hernández-Barrera6Lars Arendt-Nielsen7Juan Torres-Macho8Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), 28922 Madrid, SpainDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), 28922 Madrid, SpainDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), 28922 Madrid, SpainDepartment of Neurology, Hospital Clínico San Carlos, 28040 Madrid, SpainIntelligent Data Analysis Laboratory, Department of Electronic Engineering, ETSE (Engineering School), Universitat de València (UV), 46010 Valencia, SpainIntelligent Data Analysis Laboratory, Department of Electronic Engineering, ETSE (Engineering School), Universitat de València (UV), 46010 Valencia, SpainDepartment of Public Health, Universidad Rey Juan Carlos (URJC), 28922 Madrid, SpainCNAP, Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, DenmarkDepartment of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, SpainThis study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (<i>p</i> < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (<i>p</i> < 0.01). The mean number of post-COVID-19 symptoms was higher (<i>p</i> < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (<i>p</i> < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (<i>p</i> = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (<i>p</i> = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants.https://www.mdpi.com/2076-0817/11/7/725COVID-19post-COVID-19variantdeltaalphaWuhan |
| spellingShingle | César Fernández-de-las-Peñas Ignacio Cancela-Cilleruelo Jorge Rodríguez-Jiménez Victor Gómez-Mayordomo Oscar J. Pellicer-Valero José D. Martín-Guerrero Valentín Hernández-Barrera Lars Arendt-Nielsen Juan Torres-Macho Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant Pathogens COVID-19 post-COVID-19 variant delta alpha Wuhan |
| title | Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant |
| title_full | Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant |
| title_fullStr | Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant |
| title_full_unstemmed | Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant |
| title_short | Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant |
| title_sort | associated onset symptoms and post covid 19 symptoms in hospitalized covid 19 survivors infected with wuhan alpha or delta sars cov 2 variant |
| topic | COVID-19 post-COVID-19 variant delta alpha Wuhan |
| url | https://www.mdpi.com/2076-0817/11/7/725 |
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