Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice
Monoclonal antibodies are highly effective medications, which made a breakthrough in medicine. Taking into consideration the properties of monoclonal antibodies safety plays a key role in “risk-benefit” assessment. For monoclonal antibodies this remains studied insufficiently. The article presents a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Izdatelstvo OKI
2019-10-01
|
| Series: | Качественная клиническая практика |
| Subjects: | |
| Online Access: | https://www.clinvest.ru/jour/article/view/454 |
| _version_ | 1797262057318383616 |
|---|---|
| author | A. V. Philippova A. S. Kolbin E. V. Verbitskaya S. V. Glagolev V. A. Polivanov |
| author_facet | A. V. Philippova A. S. Kolbin E. V. Verbitskaya S. V. Glagolev V. A. Polivanov |
| author_sort | A. V. Philippova |
| collection | DOAJ |
| description | Monoclonal antibodies are highly effective medications, which made a breakthrough in medicine. Taking into consideration the properties of monoclonal antibodies safety plays a key role in “risk-benefit” assessment. For monoclonal antibodies this remains studied insufficiently. The article presents a systemic characteristic of safety profile of monoclonal antibodies used in rheumatology, based on the database of spontaneous reports of the Federal Service for the Supervision of Healthcare. Specified greater alertness of Russian practitioners regarding the risk of developing tuberculosis infections in comparison to their foreign counterparts. Spontaneous reports of the development of neoplasms and deviations of laboratory tests, according to our data, on the contrary, are reported less. It is advisable to draw the attention of practitioners to the peculiarities of work with isolated deviations in laboratory tests and keep alert about the safety issues of monoclonal antibodies in general. It is important to continue monitoring to characterize delayed type D adverse drug reactions. |
| first_indexed | 2024-04-24T23:51:03Z |
| format | Article |
| id | doaj.art-a63433537fe347d8a64e1da655b57c2c |
| institution | Directory Open Access Journal |
| issn | 2588-0519 2618-8473 |
| language | Russian |
| last_indexed | 2024-04-24T23:51:03Z |
| publishDate | 2019-10-01 |
| publisher | Izdatelstvo OKI |
| record_format | Article |
| series | Качественная клиническая практика |
| spelling | doaj.art-a63433537fe347d8a64e1da655b57c2c2024-03-14T18:09:08ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732019-10-0102758410.24411/2588-0519-2019-10075447Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practiceA. V. Philippova0A. S. Kolbin1E. V. Verbitskaya2S. V. Glagolev3V. A. Polivanov4Первый Санкт-Петербургский государственный медицинский университет имени акад. И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени акад. И.П. Павлова; Санкт-Петербургский государственный университетПервый Санкт-Петербургский государственный медицинский университет имени акад. И.П. ПавловаФедеральная служба по надзору в сфере здравоохраненияЦентр фармаконадзора, ФГБУ «ИМЦЭУАОСМП» РосздравнадзораMonoclonal antibodies are highly effective medications, which made a breakthrough in medicine. Taking into consideration the properties of monoclonal antibodies safety plays a key role in “risk-benefit” assessment. For monoclonal antibodies this remains studied insufficiently. The article presents a systemic characteristic of safety profile of monoclonal antibodies used in rheumatology, based on the database of spontaneous reports of the Federal Service for the Supervision of Healthcare. Specified greater alertness of Russian practitioners regarding the risk of developing tuberculosis infections in comparison to their foreign counterparts. Spontaneous reports of the development of neoplasms and deviations of laboratory tests, according to our data, on the contrary, are reported less. It is advisable to draw the attention of practitioners to the peculiarities of work with isolated deviations in laboratory tests and keep alert about the safety issues of monoclonal antibodies in general. It is important to continue monitoring to characterize delayed type D adverse drug reactions.https://www.clinvest.ru/jour/article/view/454моноклональные антителамониторинг безопасностифармаконадзор |
| spellingShingle | A. V. Philippova A. S. Kolbin E. V. Verbitskaya S. V. Glagolev V. A. Polivanov Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice Качественная клиническая практика моноклональные антитела мониторинг безопасности фармаконадзор |
| title | Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| title_full | Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| title_fullStr | Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| title_full_unstemmed | Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| title_short | Systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| title_sort | systemic characteristic of safety profile of monoclonal antibodies used in rheumatology practice |
| topic | моноклональные антитела мониторинг безопасности фармаконадзор |
| url | https://www.clinvest.ru/jour/article/view/454 |
| work_keys_str_mv | AT avphilippova systemiccharacteristicofsafetyprofileofmonoclonalantibodiesusedinrheumatologypractice AT askolbin systemiccharacteristicofsafetyprofileofmonoclonalantibodiesusedinrheumatologypractice AT evverbitskaya systemiccharacteristicofsafetyprofileofmonoclonalantibodiesusedinrheumatologypractice AT svglagolev systemiccharacteristicofsafetyprofileofmonoclonalantibodiesusedinrheumatologypractice AT vapolivanov systemiccharacteristicofsafetyprofileofmonoclonalantibodiesusedinrheumatologypractice |